Gabriela Chiosis

Memorial Sloan Kettering Cancer Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

66h-index14.9kcitations380works5.12yr avg
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Research Topics

Heat shock proteins research(196), Computational Drug Discovery Methods(58), Endoplasmic Reticulum Stress and Disease(53), Protein Structure and Dynamics(42), ATP Synthase and ATPases Research(38)

Publications380 total

Mapping Dysfunctional Protein-Protein Interactions in Disease
Journal of Visualized Experiments·2025Open Access
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease
Trends in Biochemical Sciences·2025· 5 citedOpen Access
Benefits of Maternal Choline Supplementation on Aged Basal Forebrain Cholinergic Neurons (BFCNs) in a Mouse Model of Down Syndrome and Alzheimer’s Disease
Biomolecules·2025Open Access
Frontal cortex pyramidal neuron expression profiles differentiate the prodromal stage from progressive degeneration across the Alzheimer's disease spectrum
Alzheimer s & Dementia·2025· 2 citedOpen Access
Author response for "Epichaperomes: Redefining Chaperone Biology and Therapeutic Strategies in Complex Diseases"
2025
Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease
Frontiers in Molecular Neuroscience·2025· 2 citedOpen Access
Systems-Level Interactome Mapping Reveals Actionable Protein Network Dysregulation Across the Alzheimer's Disease Spectrum
2025· 1 citedOpen Access
Connectivity mapping: Integrating omics data, drug targets, and disease drivers for drug discovery and repurposing
Elsevier eBooks·2025
Epichaperomes: redefining chaperone biology and therapeutic strategies in complex diseases
RSC Chemical Biology·2025· 5 citedOpen Access
Editorial overview: Protein networks in health and disease
Current Opinion in Structural Biology·2024· 1 cited
Down syndrome frontal cortex layer III and layer V pyramidal neurons exhibit lamina specific degeneration in aged individuals
Acta Neuropathologica Communications·2024· 6 citedOpen Access
Stress biology: Complexity and multifariousness in health and disease
UNC Libraries·2024Open Access
EXTH-36. SHIFTING FROM EPIGENETICS TO THE EPICHAPEROME: HSP90 AS A THERAPEUTIC TARGET FOR H3K27M DIFFUSE MIDLINE GLIOMA (DMG)
Neuro-Oncology·2024· 1 citedOpen Access
Selective Inhibition of hsp90 Paralogs: Uncovering the Role of Helix 1 in Grp94‐Selective Ligand Binding
Proteins Structure Function and Bioinformatics·2024· 2 citedOpen Access
Phosphorylation-driven epichaperome assembly is a regulator of cellular adaptability and proliferation
Nature Communications·2024· 22 citedOpen Access
Epichaperome-targeted myocardial imaging by 124I-PU-H71 PET
Clinical and Translational Imaging·2024· 2 citedOpen Access
Cracking the chaperone code through the computational microscope
Cell Stress and Chaperones·2024· 7 citedOpen Access
N‐Glycosylation‐Induced Pathologic Protein Conformations as a Tool to Guide the Selection of Biologically Active Small Molecules
Chemistry - A European Journal·2024· 7 citedOpen Access
Introducing dysfunctional Protein-Protein Interactome (dfPPI) – A platform for systems-level protein-protein interaction (PPI) dysfunction investigation in disease
Current Opinion in Structural Biology·2024· 11 citedOpen Access
Synthesis and Characterization of Click Chemical Probes for Single-Cell Resolution Detection of Epichaperomes in Neurodegenerative Disorders
Biomedicines·2024· 5 citedOpen Access
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Frequent Co-authors

Tony Taldone(16), Anna Rodina(10), Neal Rosen(8), Ari Melnick(7), Ross L. Levine(6), Eloisi Caldas-Lopes(6), Leandro Cerchietti(6), Joungnam Kim(6), David B. Solit(5), Henri Huezo(5), Shanu Modi(4), Kamalika Moulick(4), Nian Wu(4), Hediye Erdjument‐Bromage(4), Brian S. Lucas(4), Julia Aguirre(4), Len Neckers(4), D.T. Gewirth(4), Huazhong He(4), Cristina C. Clement(3)