Curt D. Haffner

RWTH Aachen University — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

19h-index1.7kcitations36works2.02yr avg
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Research Topics

Estrogen and related hormone effects(6), Hormonal Regulation and Hypertension(5), Steroid Chemistry and Biochemistry(5), Peptidase Inhibition and Analysis(4), Calcium signaling and nucleotide metabolism(4)

Publications36 total

Microstructure-sensitive crystal plasticity and fatigue indicator modeling for LZ50 steel
International Journal of Fatigue·2025· 2 citedOpen Access
Differential recognition of HIV-stimulated IL-1β and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages
PLoS Pathogens·2021· 37 citedOpen Access
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors
ACS Medicinal Chemistry Letters·2019· 26 citedOpen Access
2,4-Diamino-8-quinazoline carboxamides as novel, potent inhibitors of the NAD hydrolyzing enzyme CD38: Exploration of the 2-position structure-activity relationships
Bioorganic & Medicinal Chemistry·2018· 13 citedOpen Access
Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility
PLoS ONE·2015· 43 citedOpen Access
Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38
Journal of Medicinal Chemistry·2015· 53 citedOpen Access
Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors
Journal of Medicinal Chemistry·2015· 127 citedOpen Access
ChemInform Abstract: Substituted N‐{3‐[(1,1‐Dioxido‐1,2‐benzothiazol‐3‐yl)(phenyl)amino]propyl}benzamide Analogues as Potent Kv1.3 Ion Channel Blockers. Part 2.
ChemInform·2011
N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 inhibitors. Part 1
Bioorganic & Medicinal Chemistry Letters·2010· 12 citedOpen Access
Substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs as potent Kv1.3 ion channel blockers. Part 2
Bioorganic & Medicinal Chemistry Letters·2010· 12 citedOpen Access
Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP)
Bioorganic & Medicinal Chemistry Letters·2008· 60 citedOpen Access
Prolyl Oligopeptidase with GSK552
2008
2‐Cyano‐4‐fluoro‐1‐thiovalylpyrrolidine Analogues as Potent Inhibitors of DPP‐IV.
ChemInform·2006· 1 cited
2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV
Bioorganic & Medicinal Chemistry Letters·2005· 26 citedOpen Access
Structure-Based Design of Potent Retinoid X Receptor α Agonists
Journal of Medicinal Chemistry·2004· 48 citedOpen Access
Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer
2003
Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity
Bioorganic & Medicinal Chemistry Letters·2003· 311 citedOpen Access
Linear Relationships between the Ligand Binding Energy and the Activation Energy of Time-dependent Inhibition of Steroid 5α-Reductase by Δ1-4-Azasteroids
Journal of Biological Chemistry·2001· 11 citedOpen Access
Identification of a Chemical Tool for the Orphan Nuclear Receptor FXR
Journal of Medicinal Chemistry·2000· 521 citedOpen Access
ChemInform Abstract: The Palladium‐Catalyzed Enyne Cycloisomerization Reaction in a General Approach to the Asymmetric Syntheses of the Picrotoxane Sesquiterpenes. Part 1. First‐Generation Total Synthesis of Corianin (V) and Formal Syntheses of Picrotoxinin (VIa) and Picrotin (VIb).
ChemInform·1999
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Frequent Co-authors

Patrick Maloney(8), J. Darren Stuart(7), Stephen V. Frye(6), J. David Becherer(5), George F. Dorsey(5), Roger N. Hiner(5), Kenneth J. Shea(5), Tiffany Carpenter(4), John C. Ulrich(4), Robert A. Mook(4), Kenneth W. Batchelor(4), H. Neal Bramson(4), D. Mark Bickett(4), Marcia L. Moss(4), Gaochao Tian(4), H. Eric Xu(3), Valerie G. Montana(3), David J. Cowan(3), David N. Deaton(3), Michael R. Jeune(3)