Gaochao Tian

Samjin Pharm (South Korea) — South Korea

Computer Science · Physical Sciences

21h-index1.7kcitations48works2.52yr avg
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Research Topics

Computational Drug Discovery Methods(6), Estrogen and related hormone effects(6), Receptor Mechanisms and Signaling(6), Pharmacogenetics and Drug Metabolism(5), Steroid Chemistry and Biochemistry(5)

Publications48 total

The Impact of Service Attitude of Medical Staff on Patient Satisfaction and the Mediating Effect of Patient Commitment
Academic journal of management and social sciences·2024· 1 citedOpen Access
The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer
2024· 4 citedOpen Access
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Proceedings of the National Academy of Sciences·2023· 21 citedOpen Access
Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function
Scientific Reports·2022· 20 citedOpen Access
Small Molecule-Mediated Allosteric Activation of the Base Excision Repair Enzyme 8-Oxoguanine DNA Glycosylase: Impact on Mitochondrial Function
Research Square (Research Square)·2022Open Access
Potent Phenylpyridine and Oxodihydrofuran Inhibitors of Cyclooxygenase-2: Optimization toward a Long Residence Time with Balanced Internal Energetics
Biochemistry·2021· 5 cited
Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer
Journal of Medicinal Chemistry·2021· 26 citedOpen Access
Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
Journal of Pharmacology and Experimental Therapeutics·2019· 28 citedOpen Access
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1
Bioorganic & Medicinal Chemistry Letters·2018· 5 citedOpen Access
Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors
Bioorganic & Medicinal Chemistry Letters·2015· 10 citedOpen Access
Mechanism of Inhibition of Fatty Acid Amide Hydrolase by Sulfonamide-Containing Benzothiazoles: Long Residence Time Derived from Increased Kinetic Barrier and Not Exclusively from Thermodynamic Potency
Biochemistry·2011· 15 citedOpen Access
Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase
European Journal of Pharmacology·2011· 13 cited
Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1
Bioorganic & Medicinal Chemistry Letters·2010· 6 cited
Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency
Journal of Medicinal Chemistry·2007· 210 citedOpen Access
Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition
Molecular Pharmacology·2006· 9 cited
Biological Regulation by Protein Phosphorylation
Encyclopedia of Molecular Cell Biology and Molecular Medicine·2006
Discovery and Development of GG745, a Potent Inhibitor of Both Isozymes of of 5α-Reductase
Kluwer Academic Publishers eBooks·2006· 26 cited
Non‐Competitive Inhibition of Solubilized Human γ‐Secretase by Pepstatin A Methylester, L‐685458, Sulfonamides and Benzodiazepines
CNS Drug Reviews·2004Open Access
Mechanism of γ-Secretase Cleavage Activation:  Is γ-Secretase Regulated through Autoinhibition Involving the Presenilin-1 Exon 9 Loop?
Biochemistry·2004· 53 cited
The Mechanism of γ-Secretase
Journal of Biological Chemistry·2003· 77 citedOpen Access
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Frequent Co-authors

Clay W. Scott(7), Judith P. Klinman(6), Marcia L. Moss(6), Stephen V. Frye(6), J. Darren Stuart(5), H. Neal Bramson(5), Jeffrey S. Albert(4), Barry Greenberg(4), Joseph A. Berry(4), Curt D. Haffner(4), Javier Suárez(4), Jeffrey Varnes(4), Philip D. Edwards(3), Mark Sylvester(3), Cynthia D. Sobotka‐Briner(3), Xiaodong Liu(3), William D. Holmes(3), Sue H. Kadwell(3), Patrick Maloney(3), Roger N. Hiner(3)