Clay W. Scott

AstraZeneca (United States) — United States

Medicine · Health Sciences

33h-index4.0kcitations84works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(15), Receptor Mechanisms and Signaling(12), Protein Kinase Regulation and GTPase Signaling(8), 3D Printing in Biomedical Research(8), Cardiac electrophysiology and arrhythmias(7)

Publications84 total

Safety Considerations of Targeting Epigenetic Mechanisms
2024
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
PLoS Biology·2022· 18 citedOpen Access
Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs
Toxicology in Vitro·2020· 46 citedOpen Access
Proteolysis‐targeting chimeras in drug development: A safety perspective
British Journal of Pharmacology·2020· 202 citedOpen Access
Developing<i>in vitro</i>assays to transform gastrointestinal safety assessment: potential for microphysiological systems
Lab on a Chip·2020· 74 citedOpen Access
Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea
Toxicological Sciences·2018· 60 citedOpen Access
Evolution in diversity of a drugs primary target class poses a challenge to standard secondary pharmacology profiling: A look to future requirements and opportunities
Journal of Pharmacological and Toxicological Methods·2018
Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity
Journal of Medicinal Chemistry·2018· 32 citedOpen Access
Detecting GI toxicity earlier than in dog: Developing the first in vitro assay to predict clinical diarrhea
Toxicology Letters·2017
Deconvoluting Kinase Inhibitor Induced Cardiotoxicity
Toxicological Sciences·2017· 39 citedOpen Access
Structure-function analysis of functionally diverse members of the cyclic amide hydrolase family of Toblerone fold enzymes
2016
REVERSIBLE AND SPECIES-SPECIFIC DEPIGMENTATION EFFECTS OF AZD3293, A BACE INHIBITOR FOR THE TREATMENT OF ALZHEIMER’S DISEASE, ARE RELATED TO BACE2 INHIBITION AND CONFINED TO EPIDERMIS AND HAIR
The Journal of Prevention of Alzheimer s Disease·2016· 20 citedOpen Access
Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors
Bioorganic & Medicinal Chemistry Letters·2015· 10 citedOpen Access
Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens
ACS Medicinal Chemistry Letters·2015· 16 citedOpen Access
Figure 1: [xCELLigence RTCA Cardio instrument (ACEA...].
2015
Cardiomyocyte Impedance Assays
2015· 4 cited
Figure 9: [Effect of blebbistatin (20 hr)...].
2015
Figure 8: [Examples of compound-induced changes in...].
2015
Figure 4: [Effect of blebbistatin, a myosin...].
2015
Developing a medium throughput cellular assay to quantify modulators of contractility using human induced pluripotent stem cell-derived cardiomyocytes
Journal of Pharmacological and Toxicological Methods·2014
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Frequent Co-authors

C.B. Caputo(14), Matthew F. Peters(13), Linda A. Sygowski(5), Mathew M. S. Lo(5), Sarah D. Lamore(4), Deidre Wilkins(4), Mark Sylvester(4), Ratan V. Bhat(3), Yvonne P. Dragan(3), Kyle L. Kolaja(3), Katharine S. Knappenberger(3), Lois Ann Lazor(3), Jianwei Liu(3), Allison L. Choy(3), Tyrrell E. Norris(3), Ann W. Fieles(3), Andre I. Salama(3), Russell C. Mauger(3), William F. Brunner(3), Dean G. Brown(3)