Mark Sylvester

Entasis Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index954citations26works0.02yr avg
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Research Topics

Antibiotic Resistance in Bacteria(8), Bacterial Genetics and Biotechnology(4), Computational Drug Discovery Methods(3), Drug Transport and Resistance Mechanisms(3), Antibiotics Pharmacokinetics and Efficacy(3)

Publications26 total

Rational design of a new antibiotic class for drug-resistant infections
Nature·2021· 135 cited
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay
Bioorganic & Medicinal Chemistry·2020· 18 citedOpen Access
Crystal Structure of Pseudomonas aeruginosa Penicillin Binding Protein 3 (PAE-PBP3) bound to ETX0462
2020
5-Carboxytetramethylrhodamine-Ampicillin Fluorescence Anisotropy-Based Assay of <i>Escherichia coli</i> Penicillin-Binding Protein 2 Transpeptidase Inhibition
ACS Infectious Diseases·2019· 13 cited
An amine protecting group deprotectable under nearly neutral oxidative conditions
Beilstein Journal of Organic Chemistry·2018· 12 citedOpen Access
Whole-Cell-Based Assay To Evaluate Structure Permeation Relationships for Carbapenem Passage through the <i>Pseudomonas aeruginosa</i> Porin OprD
ACS Infectious Diseases·2017· 43 cited
Modulating the strength of hydrogen bond acceptors to achieve low Caco2 efflux for oral bioavailability of PARP inhibitors blocking centrosome clustering
Bioorganic & Medicinal Chemistry Letters·2016· 7 cited
The SEC’s Evolving Scrutiny of Private Equity Firms: KKR Hit with an Unprecedented Enforcement Action for Broken Deal Expense Misallocation
Journal of Investment Compliance·2015
Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering
Bioorganic & Medicinal Chemistry Letters·2015· 62 citedOpen Access
Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa
Chemistry & Biology·2015· 63 cited
SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of <i>Pseudomonas aeruginosa</i> PBP3
ACS Medicinal Chemistry Letters·2015· 27 citedOpen Access
Discovery of Efficacious <i>Pseudomonas aeruginosa</i>-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model
Journal of Medicinal Chemistry·2015· 26 cited
Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-Mechanistic PK/PD Model
2015
Ketamine Psychedelic Psychotherapy: Focus on its Pharmacology, Phenomenology, and Clinical Applications
International Journal of Transpersonal Studies·2014· 50 citedOpen Access
Discovery of ATP-Competitive Inhibitors of tRNAIle Lysidine Synthetase (TilS) by High-Throughput Screening
SLAS DISCOVERY·2014· 7 citedOpen Access
Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine-3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition
Journal of Medicinal Chemistry·2014· 27 citedOpen Access
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity
Bioorganic & Medicinal Chemistry Letters·2011· 25 citedOpen Access
Addiction Liability of Pharmacotherapeutic Interventions in Obesity
Current Pharmaceutical Design·2011· 5 cited
[125I]YP20: A novel radioligand specific for the extracellular domain of the CRF1 receptor
European Journal of Pharmacology·2010
Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency
Journal of Medicinal Chemistry·2007· 210 citedOpen Access
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Frequent Co-authors

Thomas F. Durand-Réville(7), Adam B. Shapiro(7), Clay W. Scott(6), Philip D. Edwards(5), Russell C. Mauger(5), Alita A. Miller(4), April Chen(4), Rubén Tommasi(4), David Aharony(3), Gaochao Tian(3), Xiaodong Liu(3), Samir H. Moussa(3), Janelle Comita-Prevoir(3), Andrew D. Ferguson(3), Hajnalka E. Davis(3), Haris Jahić(3), John P. Mueller(3), Erika Manyak(3), Olga Quiroga(3), Michael Rooney(3)