William D. Holmes

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index2.2kcitations33works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(5), Phosphodiesterase function and regulation(5), Cancer, Hypoxia, and Metabolism(4), Cholinesterase and Neurodegenerative Diseases(4), Cancer-related Molecular Pathways(3)

Publications33 total

60.2 Religious and Spiritual Considerations in Youth in Foster Care
Journal of the American Academy of Child & Adolescent Psychiatry·2018
Development of an acidic/neutral antibody flow-through polishing step using salt-tolerant anion exchange chromatography
Pharmaceutical Bioprocessing·2015· 8 citedOpen Access
Infiltrated papules on the trunk and headaches: A case of actinic granuloma and a review of the literature
International Journal of Women’s Dermatology·2015· 10 citedOpen Access
The Great Awakening
2014
Ethical dilemmas in dermatologic surgery
Clinics in Dermatology·2012· 2 cited
The Trigeminocardiac Reflex and Dermatologic Surgery
Dermatologic Surgery·2011· 7 cited
Retraction
Science·2002· 8 cited
Achieving selectivity in a kinase ATP-binding site by targeting a single amino acid
Proceedings of the American Association for Cancer Research Annual Meeting·2002
Modulation of cyclin-dependent kinase 4 by binding of magnesium (II) and manganese (II)
Biophysical Chemistry·2002· 15 cited
Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2):  Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis
Journal of Medicinal Chemistry·2001· 267 citedOpen Access
Solution Studies of Recombinant Human Stromal-Cell-Derived Factor-1
Protein Expression and Purification·2001· 39 cited
Prevention of Chemotherapy-Induced Alopecia in Rats by CDK Inhibitors
Science·2001· 167 cited
Structure of the Tie2 RTK Domain
Structure·2000· 145 citedOpen Access
THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR
2000
THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH AN OXINDOLE INHIBITOR
2000
Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity
Science·2000· 332 cited
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B
2000
Binding Mode of the 4-Anilinoquinazoline Class of Protein Kinase Inhibitor:  X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase
Journal of Medicinal Chemistry·1999· 231 citedOpen Access
Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A
Cell·1998· 282 citedOpen Access
Dual Inhibition of Human Type 4 Phosphodiesterase Isostates by (<i>R</i>*,<i>R</i>*)-(±)-Methyl 3-Acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate
Biochemistry·1998· 3 cited
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Frequent Co-authors

Warren J. Rocque(15), Anne M. Hassell(10), Michael Luther(8), Brett Lovejoy(7), Lisa M. Shewchuk(7), Stephen T. Davis(6), James M. Veal(6), H. Neal Bramson(5), Stephen V. Frye(5), Robert T. Gampe(5), Philip A. Harris(5), R. Hunter(5), Karen Lackey(5), Michael J. Luzzio(5), Lee F. Kuyper(4), Bill Benson(4), Karen M. Dold(4), Derek J. Eberwein(4), Robert Griffin(4), Victoria B. Knick(4)