Arjan van der Flier

AVEO Oncology (United States) — United States

Medicine · Health Sciences

19h-index3.0kcitations44works4.32yr avg
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Research Topics

Cell Adhesion Molecules Research(20), Hemophilia Treatment and Research(13), Cellular Mechanics and Interactions(7), Monoclonal and Polyclonal Antibodies Research(7), Platelet Disorders and Treatments(6)

Publications44 total

Novel transferrin receptor-mediated enzyme replacement therapy efficiently treats myogenic and neurogenic aspects of Pompe disease in mice
Molecular Therapy — Methods & Clinical Development·2025· 3 citedOpen Access
Corrigendum to “Pompe disease: Unmet needs and emerging therapies” [Mol Genet Metab. 2024 Nov;143(3):108590]
Molecular Genetics and Metabolism·2025
Pompe disease: Unmet needs and emerging therapies
Molecular Genetics and Metabolism·2024· 13 cited
Anti-human-TfR-GAA efficiently clears CNS and muscle glycogen in a translatable hTfR-KI/Pompe disease mouse model
Molecular Genetics and Metabolism·2024· 1 cited
Biodistribution of recombinant factor IX, extended half-life recombinant factor IX Fc fusion protein, and glycoPEGylated recombinant factor IX in hemophilia B mice
Blood Coagulation & Fibrinolysis·2023· 7 citedOpen Access
Cover Image, Volume 69, Issue 1
Glia·2020Open Access
Mechanistic Studies of Thrombin Generation Assay to Evaluate Procoagulant Potential of Fitusiran
Blood·2020
Reducing Antithrombin in Plasma to Levels Observed in Fitusiran-Treated Patients Does Not Interfere with Coagulation Assays
Blood·2020· 1 cited
<scp>α<sub>V</sub></scp> integrins in Schwann cells promote attachment to axons, but are dispensable in vivo
Glia·2020· 13 citedOpen Access
BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice
Blood·2020· 103 citedOpen Access
Differential Efficacy of Anti-Sickling and Anti-Inflammatory Mechanisms in a Fluorescent Intravital Microscopy Dorsal Skinfold Vaso-Occlusion Model in Sickle Cell Disease Townes Mice
Blood·2019· 1 cited
A Novel Humanized Hemophilia-a Mouse Model to Facilitate Preclinical In Vivo Studies of Human Specific Fviiia-Mimetic Bispecific Antibodies
Blood·2018· 1 cited
Extravascular Distribution of Conventional and Ehl FIX Products Using In Vivo SPECT Imaging Analysis in Hemophilia B Mice
Blood·2017· 7 cited
Evaluation of Recombinant Fixfc-Xten Bleeding Efficacy in Hemophilia-B Mouse Models
Blood·2016· 6 cited
Alpha 5 Integrin Mediates Osteoarthritic Changes in Mouse Knee Joints
PLoS ONE·2016· 21 citedOpen Access
Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model
Blood·2015· 3 cited
Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten
Blood·2015
FcRn Rescues Recombinant Factor VIII Fc Fusion Protein from a VWF Independent FVIII Clearance Pathway in Mouse Hepatocytes
PLoS ONE·2015· 24 citedOpen Access
α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions <i>in vivo</i>
Journal of Cell Science·2015· 1 cited
α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions <i>in vivo</i>
Development·2015· 40 citedOpen Access
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Frequent Co-authors

Richard O. Hynes(11), Arnoud Sonnenberg(10), Robert Peters(8), Ayman Ismail(6), Zhan Liu(6), Haiyan Jiang(6), Joe Salas(6), David R. Light(6), Kwabena Badu-Nkansah(4), Denise Crowley(4), C. Baudoin(4), Volker Schellenberger(4), Nina C. Leksa(4), Ingrid Kuikman(3), John D. Kulman(3), Douglas Drager(3), Christopher J. Turner(3), Siyuan Tan(3), Reinhard Fässler(2), Luca Borradori(2)