Kim J. Krishnan

Wellcome Centre for Mitochondrial Research — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.8kcitations31works0.02yr avg
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Research Topics

Mitochondrial Function and Pathology(28), Metabolism and Genetic Disorders(20), Genetic Neurodegenerative Diseases(10), ATP Synthase and ATPases Research(6), DNA Repair Mechanisms(5)

Publications31 total

Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle
Human Molecular Genetics·2014· 43 citedOpen Access
Late-onset respiratory failure due to <i>TK2</i> mutations causing multiple mtDNA deletions
Neurology·2013· 24 citedOpen Access
C.O.2 DNM2 mutations cause multiple mtDNA deletions in muscle: A novel disorder of mtDNA maintenance
Neuromuscular Disorders·2012
Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis
Acta Neuropathologica·2012· 48 citedOpen Access
mtDNA Mutations in Brain Aging and Neurodegeneration
2011
Mitochondrial DNA deletions cause the biochemical defect observed in Alzheimer's disease
Neurobiology of Aging·2011· 96 cited
Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis
Annals of Neurology·2010· 370 citedOpen Access
Repeats, longevity and the sources of mtDNA deletions: evidence from ‘deletional spectra’
Trends in Genetics·2010· 67 citedOpen Access
Mitochondrial DNA and genetic disease
Essays in Biochemistry·2010· 18 cited
Older mothers are not at risk of having grandchildren with sporadic mtDNA deletions
Genetics in Medicine·2010· 5 citedOpen Access
Mitochondrial DNA Defects and Selective Extraocular Muscle Involvement in CPEO
Investigative Ophthalmology & Visual Science·2010· 64 citedOpen Access
Detection of Mitochondrial DNA Variation in Human Cells
Methods in molecular biology·2010· 7 cited
The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
Aging Cell·2009· 28 citedOpen Access
Bayesian Emulation and Calibration of a Stochastic Computer Model of Mitochondrial DNA Deletions in Substantia Nigra Neurons
Journal of the American Statistical Association·2009· 88 cited
Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration
Annals of the New York Academy of Sciences·2008· 145 cited
G.P.3.03 A histochemical and molecular genetic investigation of the selective, extraocular muscle involvement in chronic progressive external ophthalmoplegia
Neuromuscular Disorders·2008
Alpha‐synuclein pathology and Parkinsonism associated with <i>POLG1</i> mutations and multiple mitochondrial DNA deletions
Neuropathology and Applied Neurobiology·2008· 46 cited
Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions
Journal of Neurology·2008· 85 cited
Age related mitochondrial degenerative disorders in humans
Biotechnology Journal·2008· 63 cited
What causes mitochondrial DNA deletions in human cells?
Nature Genetics·2008· 378 cited
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Frequent Co-authors

Douglass M. Turnbull(23), Amy K. Reeve(14), Robert W. Taylor(10), Andreas Bender(5), Mark A. Birch‐Machin(5), Laura C. Greaves(4), Christopher M. Morris(3), Evelyn Jaros(3), Joanna L. Elson(3), Emma L. Blakely(3), Geoffrey A. Taylor(2), Robert H. Perry(2), Joanne Betts(2), Thomas Klopstock(2), John K. Blackwood(2), Robert N. Lightowlers(2), G. Campbell(2), Iryna Ziabreva(2), Richard Reynolds(2), Hans Lassmann(2)