Tomasz Lenda

Maj Institute of Pharmacology — Poland

Neuroscience · Life Sciences

22h-index1.2kcitations83works1.32yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(24), Parkinson's Disease Mechanisms and Treatments(21), Receptor Mechanisms and Signaling(16), Neurotransmitter Receptor Influence on Behavior(12), Neurological disorders and treatments(12)

Publications83 total

Cinnarizine, a Calcium Channel Blocker, Partially Prevents the Striatal Dopamine Decline and Loss of Nigral Dopamine Neurons in the Lactacystin-Induced Rat Model of Parkinson’s Disease
International Journal of Molecular Sciences·2025Open Access
Minocycline treatment affects astrocyte – microglia – neuron interaction and functional compensation of motor deficits in rat model of combined fluorocitrate and 6-OHDA lesion and early Parkinson’s disease
2025
Evidence for functional interaction between the CB1 and the mGlu7 receptors mediated signaling in modulation of anxiety behavior and cognition.
Life Sciences·2024· 2 cited
Simultaneous 5-HT1BR agonist/5-HT6R antagonist action as a potential treatment of Parkinson’s disease and its comorbidities
Journal of Pharmacology and Experimental Therapeutics·2024· 5 citedOpen Access
The Effect of Chronic Treatment with the Inhibitor of Phosphodiesterase 5 (PDE5), Sildenafil, in Combination with L-DOPA on Asymmetric Behavior and Monoamine Catabolism in the Striatum and Substantia Nigra of Unilaterally 6-OHDA-Lesioned Rats
Molecules·2024· 1 citedOpen Access
Evidence for Functional Interaction between the Cb1 and the Mglu7 Mediated Signaling in Modulation of Anxiety Behavior and Cognition
SSRN Electronic Journal·2024Open Access
The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition
Behavioural Brain Research·2023· 5 citedOpen Access
Behavioral and neurochemical interactions of the tricyclic antidepressant drug desipramine with L-DOPA in 6-OHDA-lesioned rats. Implications for motor and psychiatric functions in Parkinson’s disease
Psychopharmacology·2022· 4 citedOpen Access
CPL500036 – a novel inhibitor of phosphodiesterase 10A – attenuates the development of L-DOPA-induced dyskinesias in 6-OHDA lesioned rats
Neuroscience Applied·2022· 1 citedOpen Access
Upregulation of the mGlu5 receptor and COX-2 protein in the mouse brain after imipramine and NS398, searching for mechanisms of regulation
Neurochemistry International·2021· 5 cited
Evidence for the interaction of COX-2 with mGluR5 in the regulation of EAAT1 and EAAT3 protein levels in the mouse hippocampus. The influence of oxidative stress mechanisms
Brain Research·2021· 11 cited
Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease
European Journal of Pharmacology·2021· 11 citedOpen Access
N-Skatyltryptamines—Dual 5-HT6R/D2R Ligands with Antipsychotic and Procognitive Potential
Molecules·2021· 6 citedOpen Access
Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine
European Journal of Medicinal Chemistry·2021· 29 citedOpen Access
Rationally designed N-phenylsulfonylindoles as a tool for the analysis of the non-basic 5-HT6R ligands binding mode
European Journal of Medicinal Chemistry·2020· 3 citedOpen Access
P.105 The study of molecular changes induced by CPL500-036, a potential novel anti-dyskinetic drug, in 6-OHDA rat model of Parkinson's disease
European Neuropsychopharmacology·2020· 1 cited
Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5′-Chloro-5′-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor
Neuroscience·2020· 18 cited
Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties
European Journal of Medicinal Chemistry·2019· 37 citedOpen Access
2-Aminoimidazole-based antagonists of the 5-HT6 receptor – A new concept in aminergic GPCR ligand design
European Journal of Medicinal Chemistry·2019· 21 citedOpen Access
Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers
European Journal of Medicinal Chemistry·2019· 33 citedOpen Access
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Frequent Co-authors

Jolanta Konieczny(23), Elżbieta Lorenc‐Koci(16), Grzegorz Satała(13), Andrzej J. Bojarski(13), Kinga Kamińska(10), Anna Czarnecka(9), Maria Śmiałowska(8), Ryszard Bugno(8), Beata Duszyńska(7), Rafał Kurczab(7), Jakub Staroń(7), Adam S. Hogendorf(7), Agata Hogendorf(7), Krystyna Ossowska(6), Paweł Zajdel(6), Jadwiga Wardas(5), Joanna M. Wierońska(5), Andrzej Pilc(5), Helena Domin(5), Lucyna Antkiewicz‐Michaluk(5)