Iain D. C. Fraser

National Institutes of Health — United States

Immunology and Microbiology · Life Sciences

50h-index15.9kcitations213works7.32yr avg
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Research Topics

Immune Response and Inflammation(37), Immune cells in cancer(20), Blood groups and transfusion(17), Protein Kinase Regulation and GTPase Signaling(12), Inflammasome and immune disorders(12)

Publications212 total

Taurine and a-ketoglutarate induce innate immune memory in macrophages and facilitate the reactivation of latently infected HIV by β-glucan and MDP 9276
The Journal of Immunology·2025Open Access
Innate Immune Memory in Myeloid Cells Can Reactivate Latent HIV-1 from HAART suppressed PBMCs of PLWH by Enhanced Cross Talk with Lymphoid Cells 9274
The Journal of Immunology·2025Open Access
Innate Immune Memory induced by MDP, B-glucan or SYK Inhibition Accelerates Trained Immunity-Based Elimination of HIV Infected Cells from PBMCs of PLWH 9273
The Journal of Immunology·2025Open Access
IFIT1 suppresses the infection of RSV by modulating microRNA-mediated regulation of IL1-b levels 9275
The Journal of Immunology·2025Open Access
Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis
PROTEOMICS·2025· 1 citedOpen Access
PP3.2 – 00156 Endogenous Cytokine Reporter Macrophages Facilitate Identification of Novel Training Compounds that can Reactivate and Initiate Clearance of Latent HIV
Journal of Virus Eradication·2024Open Access
PP3.1 – 00160 Macrophage Training Reactivates Latent HIV-1 from HAARTsuppressed PBMCs of PLWH
Journal of Virus Eradication·2024Open Access
Bactericidal antibiotic treatment induces damaging inflammation via TLR9 sensing of bacterial DNA
Nature Communications·2024· 11 citedOpen Access
Efficient electroporation in primary cells with PEDOT:PSS electrodes
Science Advances·2024· 12 citedOpen Access
IL-10 dependent adaptation allows macrophages to adjust inflammatory responses to TLR4 stimulation history
2024· 1 citedOpen Access
Arachidonic acid inhibition of the NLRP3 inflammasome is a mechanism to explain the anti-inflammatory effects of fasting
Cell Reports·2024· 62 citedOpen Access
hcHCR: High-Throughput Single-Cell Imaging of RNA in Human Primary Immune Cells
Methods in molecular biology·2024· 1 citedOpen Access
Identification of age-specific gene regulators of La Crosse virus neuroinvasion and pathogenesis
Nature Communications·2023· 14 citedOpen Access
Developing a Robust and High Throughput Assay for Screening Innate Immune Training Molecules
The Journal of Immunology·2023· 1 citedOpen Access
Targeted proteomics-driven computational modeling of the mouse macrophage toll-like receptor signaling pathway
The Journal of Immunology·2023· 1 citedOpen Access
UBL5 Modulates Expression of Crucial TLR Pathway Genes and Inflammasome Activation in Human Macrophage Cells
The Journal of Immunology·2023Open Access
Innate Immune Training Enhances the Reactivation of Latently Infected HIV-1 from Monocytic Cell lines
The Journal of Immunology·2023Open Access
Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis
The Journal of Immunology·2023· 1 citedOpen Access
Defining how Antibiotic Treatments shape Host Immunity
The Journal of Immunology·2023Open Access
Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis
Cell Death and Differentiation·2023· 32 citedOpen Access
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Frequent Co-authors

Melvin I. Simon(6), John D. Scott(5), Ronald N. Germain(5), Steven B. Marston(5), Tamara I. A. Roach(4), Paul C. Sternweis(4), Jamie Liu(4), Rachel A. Gottschalk(4), R.E. Stofko-Hahn(3), J.D. Scott(3), Keng Lin(3), Robert C. Hsueh(3), Robert A. Rebres(3), Elliott M. Ross(3), Estelle A. Wall(3), Joelle R. Zavzavadjian(3), Leah A. Santat(3), William E. Seaman(3), Joy Bothamley(3), Robert J. Lefkowitz(3)