Dean J. Naisbitt

University of Liverpool — United Kingdom

Medicine · Health Sciences

56h-index11.3kcitations281works3.52yr avg
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Research Topics

Drug-Induced Adverse Reactions(154), Asthma and respiratory diseases(65), Drug-Induced Hepatotoxicity and Protection(44), Mast cells and histamine(42), Immune Cell Function and Interaction(38)

Publications278 total

Current drug hypersensitivity challenges facing patients with cystic fibrosis
Journal of Cystic Fibrosis·2026Open Access
Covalent binding of flucloxacillin to 14-3-3 proteins promotes naive T-cell activation
Journal of Allergy and Clinical Immunology·2026Open Access
Phenotypic and functional characterisation of liver-infiltrating T-cells in a case of CFTR modulator induced drug-induced liver injury
Journal of Cystic Fibrosis·2025Open Access
Nitazoxanide Shows an Immunomodulatory Effect in Vγ9Vδ2 T Cells
Scientia Pharmaceutica·2025Open Access
The deglycosylated metabolite of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D- glucoside contributes to immune-mediated hepatotoxicity induced by Polygonum multiflorum
Archives of Toxicology·2025· 1 cited
P17-01 Developing novel methods to assess MHC-peptide interactions in the prediction of T-cell mediated drug immunogenicity
Toxicology Letters·2025
Adverse drug reaction to contrast medium after anti-PD-1 therapy
Postgraduate Medical Journal·2025· 1 cited
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity
Signal Transduction and Targeted Therapy·2025· 1 citedOpen Access
Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS
Toxicological Sciences·2025· 2 cited
Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An <scp>EAACI</scp> Task Force Report
Allergy·2025· 5 citedOpen Access
Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi
Chemical Research in Toxicology·2025· 1 citedOpen Access
Immunogenic adverse events to CFTR modulators – An international survey
Journal of Cystic Fibrosis·2025· 5 citedOpen Access
Understanding mechanisms of thrombosis and thrombocytopenia with adenoviral SARS-CoV-2 vaccines: a comprehensive synopsis
Efficacy and Mechanism Evaluation·2025Open Access
Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS.
2024
Prospective Piperacillin Lymphocyte Transformation Testing in Patients With Cystic Fibrosis Receiving Regular and Desensitization Courses of Piperacillin-Tazobactam
The Journal of Allergy and Clinical Immunology In Practice·2024Open Access
CYP3A4-Mediated Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor JNJ-54861911 Results in Redox-Neutral Addition of Glutathione via Catalysis by Glutathione S-Transferase α1, Identified as the Major Target Protein in Human Hepatocytes
Chemical Research in Toxicology·2024· 3 cited
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Clinical & Experimental Allergy·2024Open Access
Polyfunctional T cells and unique cytokine clusters imprint the anti rAAV2/rAAV9 vector immune response
Frontiers in Immunology·2024· 2 citedOpen Access
Feedback regulation of <scp>VISTA</scp> and Treg by <scp>TNF</scp>‐α controls T cell responses in drug allergy
Allergy·2024· 4 citedOpen Access
Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities
Toxicological Sciences·2024· 2 citedOpen Access
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Frequent Co-authors

Munir Pirmohamed(30), John Farrell(13), Werner J. Pichler(12), Dominic P. Williams(10), B. Kevin Park(8), Rosalind E. Jenkins(7), James L. Maggs(7), Neil French(6), Jan P.H. Depta(5), B. Kevin Park(5), Neil R. Kitteringham(5), Christopher E. Goldring(4), Stephen E. Clarke(4), Christoph Burkhart(4), S.F. Gordon(4), Xiaoli Meng(4), B. Kevin Park(3), Manal Monshi(3), Lee Faulkner(3), Caroline J. Earnshaw(3)