Dominic P. Williams

AstraZeneca (United Kingdom) — United Kingdom

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

52h-index8.8kcitations176works6.02yr avg

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Research Topics

Drug-Induced Hepatotoxicity and Protection(56), Pharmacogenetics and Drug Metabolism(49), Liver physiology and pathology(19), Computational Drug Discovery Methods(16), Liver Disease Diagnosis and Treatment(15)

Publications176 total

Apoptotic signatures allow early and rapid screening of drug-induced liver injury to accelerate drug discovery

Communications Medicine·2025Open Access

Mitotoxic effects of the melanin-concentrating hormone receptor 1 (MCHr1) antagonist AZD1979 are influenced by mitochondrial DNA variation in HepG2 cybrids

1 cited

Toxicology·2025· 1 citedOpen Access

Contemporary perspective and practical application of glutamate dehydrogenase in nonclinical studies

Biomarkers in Medicine·2025Open Access

Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017

Chemical Research in Toxicology·2025

Hepatic cellular stress response pathways exhibit species differences in basal and inducible activity

2025Open Access

Peripheral Macular Endothelial Dystrophy: Clinical, Histopathologic, Genetic and Functional Characterization

American Journal of Ophthalmology·2025

Use of new approach methodology for hepatic safety assessment of covalent inhibitor drug candidates

Toxicology Research·2025

Machine Learning for Toxicity Prediction Using Chemical Structures: Pillars for Success in the Real World

50 cited

Chemical Research in Toxicology·2025· 50 citedOpen Access

P02-26 Optimized iPSC-derived hepatocytes offer a novel liver cell model for in vitro predictive toxicity and drug efficacy studies

Toxicology Letters·2024

Structural characterization of thioredoxin reductase from Cryptosporidium parvum and its interaction with auranofin

Acta Crystallographica Section A Foundations and Advances·2024Open Access

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted In Vivo and In Vitro Data

30 cited

Chemical Research in Toxicology·2024· 30 citedOpen Access

FRI-542 Induced pluripotent stem cell-derived hepatocytes revisited: improved liver functionality compared to liver cancer cell lines and a better model for pre-clinical large-scale therapeutic screening and drug safety

Journal of Hepatology·2024

Abstract 7094: Clinical metabolomics reveals baseline biomarkers of hepatic dysfunction correlating with irregular drug-induced ALT and bilirubin elevations

Cancer Research·2024

Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells

3 cited

PLoS ONE·2024· 3 citedOpen Access

Improved Detection of Drug-Induced Liver Injury by Integrating Predicted in vivo and in vitro Data

6 cited

2024· 6 citedOpen Access

Keratitis Fugax Hereditaria Associated With a Novel NLRP3 Mutation in a Non-Finnish Patient

1 cited

Cornea·2023· 1 cited

P25-14: Hepatic safety assessment of covalent inhibitor drug candidates

Toxicology Letters·2023

Identification of a novel partial deletion of STS associated with pre-Descemet corneal dystrophy and X-linked ichthyosis.

1 cited

PubMed·2023· 1 citedOpen Access

Novel DCN Mutation in Armenian Family With Congenital Stromal Corneal Dystrophy

6 cited

Cornea·2022· 6 cited

SOC-IV-08 Defining the importance of the mitochondrial genome in the role of NAFLD using 3D in vitro transmitochondrial cybrid steatotic and fibrotic models

Toxicology Letters·2022

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Frequent Co-authors

Munir Pirmohamed(11), Dean J. Naisbitt(11), Daniel J. Antoine(9), Neil R. Kitteringham(8), Christopher E. Goldring(8), Abhishek Srivastava(7), James L. Maggs(7), B. Kevin Park(6), Lorna Ewart(5), Alison J. Foster(5), Sophie Regan(5), B. Kevin Park(5), Kyung‐Jin Jang(4), Rosalind E. Jenkins(4), Paul Morgan(4), Laura E. Randle(4), Konstantia Kodella(3), Debora B. Petropolis(3), Jonathan E. Rubins(3), Geraldine A. Hamilton(3)