Amanda Larson Gedman

St. Jude Children's Research Hospital — United States

Medicine · Health Sciences

11h-index4.2kcitations26works0.02yr avg
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Research Topics

Acute Myeloid Leukemia Research(10), Acute Lymphoblastic Leukemia research(9), Cancer Genomics and Diagnostics(7), Protein Degradation and Inhibitors(6), Cancer-related gene regulation(5)

Publications26 total

AMKL chimeric transcription factors are potent inducers of leukemia
Leukemia·2017· 40 citedOpen Access
The genomic landscape of core-binding factor acute myeloid leukemias
Nature Genetics·2016· 264 citedOpen Access
Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis
Cell·2015· 2.5k citedOpen Access
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias
Nature Genetics·2015· 486 citedOpen Access
Novel AMKL Chimeric Transcription Factors Are Potent Inducers of Leukemia with Unique Mechanisms of Leukemogenesis
Blood·2014
Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project
Blood·2014· 12 cited
Abstract A15: The landscape of somatic mutations in the core-binding factor acute myeloid leukemias
Cancer Research·2014
Identification and Characterization of Novel Fusion Proteins in Pediatric Acute Megakaryoblastic Leukemia
Clinical Lymphoma Myeloma & Leukemia·2014
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
Nature Communications·2014· 387 citedOpen Access
Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells
Journal of Biological Chemistry·2013· 49 citedOpen Access
Abstract 4116: Notch1 regulates AKT-T308 dephosphorylation through modulation of the PP2A phosphatase in GSI-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells.
Cancer Research·2013· 1 cited
Abstract 3178: Deep sequencing of immunophenotypically distinct subsets in acute myeloid leukemia reveals reservoirs of genetically distinct subclones along a conserved differentiation trajectory.
Cancer Research·2013
An Inv(16)(p13.3q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein Defines an Aggressive Subtype of Pediatric Acute Megakaryoblastic Leukemia
Cancer Cell·2012· 273 citedOpen Access
Abstract 4867: Identification of an inv(16)-encoded <i>CBFA2T3-GLIS2</i> fusion protein in 34% of non-infant acute megkaryoblastic leukemias: A report from the Pediatric Cancer Genome Project
Cancer Research·2012
Abstract 2226: Mechanisms for cross-talk between Notch1 and AKT signaling in T-cell acute lymphoblastic leukemia
Cancer Research·2012
Abstract 4869: Whole genome sequence analysis of MLL rearranged infant acute lymphoblastic leukemias reveals remarkably few somatic mutations: A Report From the St Jude Children's Research Hospital - Washington University Pediatric Cancer Genome Project
Cancer Research·2012· 13 cited
Transcriptome Sequence Analysis of Pediatric Acute Megakaryoblastic Leukemia Identifies An Inv(16)(p13.3;q24.3)-Encoded CBFA2T3-GLIS2 Fusion Protein As a Recurrent Lesion in 39% of Non-Infant Cases: A Report From the St. Jude Children's Research Hospital – Washington University Pediatric Cancer Genome Project
Blood·2011· 1 cited
Whole Genome Sequence Analysis of 22 MLL Rearranged Infant Acute Lymphoblastic Leukemias Reveals Remarkably Few Somatic Mutations: A Report From the St Jude Children‘s Research Hospital - Washington University Pediatric Cancer Genome Project
Blood·2011· 8 cited
Abstract 2881: Posttranslational inactivation of PTEN promoted by loss of Notch1 signaling in T-ALL
Cancer Research·2011
Abstract 4360: Loss of NOTCH1 is associated with decreased expression of hsa-miR-125a-5p in T-cell acute lymphoblastic leukemia: Implications for using NOTCH1 inhibition in chemotherapy
Cancer Research·2010
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Frequent Co-authors

James R. Downing(14), Tanja A. Grüber(12), John Easton(11), Jinghui Zhang(11), Sheila Shurtleff(10), Larry H. Matherly(10), Jing Ma(9), Michael Rusch(9), Elaine R. Mardis(9), Richard K. Wilson(9), Anna Andersson(8), Li Ding(8), Ching‐Hon Pui(8), Jeffrey W. Taub(8), Xiang Chen(7), Jinjun Dang(7), Gang Wu(7), Matthew Parker(6), Charles G. Mullighan(6), Jinjun Cheng(6)