Nelson S. Yew

AVEO Oncology (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index4.7kcitations71works0.02yr avg
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Research Topics

RNA Interference and Gene Delivery(30), Virus-based gene therapy research(20), Lysosomal Storage Disorders Research(11), Reproductive Biology and Fertility(9), Transplantation: Methods and Outcomes(7)

Publications71 total

Excretion of excess nitrogen and increased survival by loss of <scp>SLC6A19</scp> in a mouse model of ornithine transcarbamylase deficiency
Journal of Inherited Metabolic Disease·2022· 8 cited
Comparison of Microflow and Analytical Flow Liquid Chromatography Coupled to Mass Spectrometry Global Metabolomics Methods Using a Urea Cycle Disorder Mouse Model
Journal of Proteome Research·2021· 8 citedOpen Access
Inhibiting neutral amino acid transport for the treatment of phenylketonuria
JCI Insight·2018· 46 citedOpen Access
AAV8-mediated expression of N-acetylglucosamine-1-phosphate transferase attenuates bone loss in a mouse model of mucolipidosis II
Molecular Genetics and Metabolism·2016· 13 cited
Erythrocytes encapsulated with phenylalanine hydroxylase exhibit improved pharmacokinetics and lowered plasma phenylalanine levels in normal mice
Molecular Genetics and Metabolism·2013· 28 cited
Adeno‐associated virus‐mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E<sup>−/−</sup> mice
The Journal of Gene Medicine·2011· 17 cited
Increased Hepatic Insulin Action in Diet-Induced Obese Mice Following Inhibition of Glucosylceramide Synthase
PLoS ONE·2010· 30 citedOpen Access
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma
International Immunology·2010· 32 cited
Inhibition of osteoclastogenesis by prolyl hydroxylase inhibitor dimethyloxallyl glycine
Journal of Bone and Mineral Metabolism·2010· 34 cited
Dual-Action Lipophilic Iminosugar Improves Glycemic Control in Obese Rodents by Reduction of Visceral Glycosphingolipids and Buffering of Carbohydrate Assimilation
Journal of Medicinal Chemistry·2009· 96 citedOpen Access
Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice Potential conflict of interest: Nothing to report.
2009
Inhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice #
Hepatology·2009· 89 citedOpen Access
Systemic Insulin-like Growth Factor-1 Reverses Hypoalgesia and Improves Mobility in a Mouse Model of Diabetic Peripheral Neuropathy
Molecular Therapy·2008· 48 citedOpen Access
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
Nature Biotechnology·2008· 294 cited
<i>Mos</i> Proto‐Oncogene Function
Novartis Foundation symposium·2007· 4 cited
Timing of Therapeutic Intervention Determines Functional and Survival Outcomes in a Mouse Model of Late Infantile Batten Disease
Molecular Therapy·2007· 80 citedOpen Access
Inhibiting Glycosphingolipid Synthesis Improves Glycemic Control and Insulin Sensitivity in Animal Models of Type 2 Diabetes
Diabetes·2007· 238 citedOpen Access
Influence of CpG-dinucleotide motifs on the duration of gene expression from plasmid, vectors after in vivo lung delivery
Oxford University Research Archive (ORA) (University of Oxford)·2007
893. Second Generation Gene Therapy Vector for Classical Late Infantile Neuronal Ceroid Lipofuscinosis
Molecular Therapy·2006Open Access
786. Development of Zero-CpG Plasmids with Reduced Inflammatory Responses Following Delivery of Lipid/pDNA Complexes to the Mouse Lung
Molecular Therapy·2006Open Access
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Frequent Co-authors

Seng H. Cheng(22), Ronald K. Scheule(14), Robin J. Ziegler(10), Malgorzata Przybylska(10), George F. Vande Woude(8), John Marshall(7), Canwen Jiang(7), Craig Siegel(4), Hongmei Zhao(4), Jennifer D. Tousignant(4), Robert J. Desnick(4), Bassem N. Mora(4), Kathryn X. Wang(3), I-Huan Wu(3), I‐Huan Wu(3), Shuk Han Cheng(3), Maribeth Cherry(3), Ira Daar(3), Chester Li(3), G. Alexander Patterson(3)