John Marshall

Virginia–Maryland College of Veterinary Medicine — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index11.1kcitations126works0.02yr avg
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Research Topics

RNA Interference and Gene Delivery(23), Lysosomal Storage Disorders Research(22), Virus-based gene therapy research(19), Ion channel regulation and function(15), Cystic Fibrosis Research Advances(13)

Publications126 total

A method for discovery of transcription factors controlling <i>Brucella</i> sRNAs
Microbiology Spectrum·2025Open Access
Correction: A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro
PLoS ONE·2024Open Access
Author response for "Structure‐based design of peptidomimetic inhibitors of &lt;scp&gt;PSD&lt;/scp&gt;‐95 with improved affinity for the &lt;scp&gt;PDZ3&lt;/scp&gt; domain"
2023
Gb3‐cSrc complex in glycosphingolipid‐enriched microdomains contributes to the expression of p53 mutant protein and cancer drug resistance via β‐catenin–activated RNA methylation
FASEB BioAdvances·2020· 18 citedOpen Access
Adeno-associated viral vectored delivery of a monoclonal antibody gene against blood-stage malaria
Human Gene Therapy·2019
Substrate Reduction Therapy for Sandhoff Disease through Inhibition of Glucosylceramide Synthase Activity
Molecular Therapy·2019· 51 citedOpen Access
Adeno-Associated Viral Vectored Delivery of a Novel Monoclonal Antibody Gene against Blood-Stage Plasmodium Falciparum Malaria
Oxford University Research Archive (ORA) (University of Oxford)·2018Open Access
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
Proceedings of the National Academy of Sciences·2017· 196 citedOpen Access
A thermally stabilised version of Plasmodium falciparum RH5
2016
504: PHENOBARBITAL VERSUS BENZODIAZEPINES IN THE TREATMENT OF ALCOHOL WITHDRAWAL SYNDROME
Critical Care Medicine·2016· 1 cited
Modulating ryanodine receptors with dantrolene attenuates neuronopathic phenotype in Gaucher disease mice
Human Molecular Genetics·2016· 34 citedOpen Access
CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease
Molecular Therapy·2016· 100 citedOpen Access
Glucosylceramide synthase inhibition reduces α-synuclein pathology and improves cognition in murine models of synucleinopathy
Molecular Genetics and Metabolism·2016
Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease
Molecular Medicine·2015· 99 citedOpen Access
α-Galactosidase A Knockout Mice
American Journal Of Pathology·2014· 41 citedOpen Access
Proteinase-Activated Receptor-1 Mediates Elastase-Induced Apoptosis of Human Lung
2013
Correction: Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
PLoS Biology·2013· 24 citedOpen Access
A novel, selective and orally-available glucosylceramide synthase inhibitor for substrate reduction therapy of Fabry disease
Molecular Genetics and Metabolism·2013
Merits of Combination Cortical, Subcortical, and Cerebellar Injections for the Treatment of Niemann-Pick Disease Type A
Molecular Therapy·2012· 29 citedOpen Access
Iminosugar-based inhibitors of glucosylceramide synthase prolong survival but paradoxically increase brain glucosylceramide levels in Niemann–Pick C mice
Molecular Genetics and Metabolism·2012· 61 cited
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Frequent Co-authors

Seng H. Cheng(25), Jennifer B. Nietupski(12), Ronald K. Scheule(12), Alan E. Smith(9), Michael J. Welsh(7), Karen M. Ashe(7), Richard J. Gregory(6), Dinesh S. Bangari(6), Craig Siegel(5), Nelson S. Yew(5), Robin J. Ziegler(5), Diane Copeland(5), Edward R. Lee(4), Kathryn X. Wang(4), Shuk Han Cheng(4), Kerry Anne McEachern(4), John P. Leonard(4), Wei‐Lien Chuang(4), Canwen Jiang(3), David J. Harris(3)