Alexandr A. Kapralov

University of Health Sciences Antigua — AG

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index13.6kcitations107works19.52yr avg
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Research Topics

Mitochondrial Function and Pathology(29), Ferroptosis and cancer prognosis(21), Photosynthetic Processes and Mechanisms(14), Graphene and Nanomaterials Applications(14), RNA modifications and cancer(12)

Publications107 total

Antiferroptotic Drugs Reduce sFlt-1 Release and Placenta Damage in Preeclampsia
Hypertension·2025· 3 cited
15-Lipoxygenase-dependent radiomitigation by NO●-Donors suppresses ferroptosis in intestinal Epithelium: Multiomics MS imaging and LC-MS evidence
Redox Biology·2025Open Access
Compartmentalized mitochondrial ferroptosis converges with optineurin-mediated mitophagy to impact airway epithelial cell phenotypes and asthma outcomes
Nature Communications·2024· 23 citedOpen Access
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
Cell Metabolism·2024· 49 citedOpen Access
Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death
Angewandte Chemie International Edition·2024· 42 citedOpen Access
Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death
Angewandte Chemie·2024Open Access
Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome
Nature Metabolism·2023· 20 citedOpen Access
Membrane regulation of 15LOX-1/PEBP1 complex prompts the generation of ferroptotic signals, oxygenated PEs
Free Radical Biology and Medicine·2023· 14 citedOpen Access
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators
Proceedings of the National Academy of Sciences·2023· 23 citedOpen Access
Formation of protein adducts with Hydroperoxy-PE electrophilic cleavage products during ferroptosis
Redox Biology·2023· 25 citedOpen Access
Vitamin E/Coenzyme Q-Dependent “Free Radical Reductases”: Redox Regulators in Ferroptosis
Antioxidants and Redox Signaling·2023· 18 citedOpen Access
Visualizing Cardiolipin In Situ with HKCL-1M, a Highly Selective and Sensitive Fluorescent Probe
Journal of the American Chemical Society·2023· 22 citedOpen Access
Redox phospholipidomics discovers pro-ferroptotic death signals in A375 melanoma cells in vitro and in vivo
Redox Biology·2023· 42 citedOpen Access
Membrane Regulation of 15LOX-1/PEBP1 Complex Prompts the Generation of Ferroptotic Signals, Oxygenated PEs
SSRN Electronic Journal·2023Open Access
P. aeruginosa augments irradiation injury via 15-lipoxygenase–catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis
JCI Insight·2022· 42 citedOpen Access
Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death
Redox Biology·2022· 42 citedOpen Access
A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO• sabotage of theft-ferroptosis
Redox Biology·2021· 83 citedOpen Access
Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes
Redox Biology·2021· 182 citedOpen Access
NO● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis
International Journal of Molecular Sciences·2021· 40 citedOpen Access
Direct Mapping of Phospholipid Ferroptotic Death Signals in Cells and Tissues by Gas Cluster Ion Beam Secondary Ion Mass Spectrometry (GCIB‐SIMS)
Angewandte Chemie International Edition·2021· 67 citedOpen Access
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Frequent Co-authors

Valerian E. Kagan(50), Vladimir A. Tyurin(29), Yulia Y. Tyurina(28), Hülya Bayır(24), Andrew A. Amoscato(19), Tamil S. Anthonymuthu(13), Irina I. Vlasova(13), Claudette M. St. Croix(12), Haider H. Dar(12), Judith Klein‐Seetharaman(12), Alexander Star(11), Jianfei Jiang(10), İvet Bahar(10), Joel S. Greenberger(10), Natalia A. Belikova(10), Anna A. Shvedova(10), Simon C. Watkins(9), Naveena Yanamala(8), Indira H. Shrivastava(7), Zhentai Huang(7)