Paul L. Chariou

AstraZeneca (United States) — United States

Agricultural and Biological Sciences · Life Sciences

16h-index1.1kcitations32works1.02yr avg
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Research Topics

Plant Virus Research Studies(9), Cancer Immunotherapy and Biomarkers(8), Bacteriophages and microbial interactions(8), Immune cells in cancer(6), Histone Deacetylase Inhibitors Research(6)

Publications32 total

470 Multimodal profiling reveals unique and overlapping features of rilvegostomig and PD(x) activity in NSCLC tumor explants
Regular and Young Investigator Award Abstracts·2025Open Access
465 Unraveling rilvegostomig’s binding characteristics: TIGIT anchoring increases PD-1 saturation through coordinated engagement
Regular and Young Investigator Award Abstracts·2025Open Access
694 Potent combination activity of B7-H4 TOP1i ADC puxitatug samrotecan with the monovalent bispecific anti-PD-1/TIGIT antibody rilvegostomig and PARP1 inhibitor saruparib in experimental cancer models
Regular and Young Investigator Award Abstracts·2025Open Access
OA03.03 Rilvegostomig Enhances Ex Vivo Immune Activation in Patient-Resected NSCLC Tumors Over PDx or PDX/aTIGIT Combination Therapy
Journal of Thoracic Oncology·2025
483 Dual blockage of PD-1 and TIGIT with rilvegostomig inhibits tumor growth in various in vitro/in vivo/ex vivo tumor models through effector CD8 activation and immune modulation
Regular and Young Investigator Award Abstracts·2024· 2 citedOpen Access
807 The PD1-TIM3 bispecific antibody sabestomig combines with a topoisomerase 1 inhibitor-conjugated ADC for additive anti-tumor activity and tumor immune modulation in a novel humanized NSCLC mouse model
Regular and Young Investigator Award Abstracts·2024Open Access
Magnetically Induced Thermal Effects on Tobacco Mosaic Virus-Based Nanocomposites for a Programmed Disassembly of Protein Cages
ACS Applied Bio Materials·2024· 4 citedOpen Access
Abstract 4065: Entinostat synergizes with the IL-15 superagonist N-803 and anti-PD-1 to engage cDC1 and stem-like TCF-1+ CD8+ T and NK cells to overcome colorectal tumors refractory to anti-PD-1 therapy
Cancer Research·2024· 1 cited
Generation of murine tumor models refractory to αPD-1/-L1 therapies due to defects in antigen processing/presentation or IFNγ signaling using CRISPR/Cas9
PLoS ONE·2024· 2 citedOpen Access
Exploiting docetaxel-induced tumor cell necrosis with tumor targeted delivery of IL-12
Cancer Immunology Immunotherapy·2023· 4 citedOpen Access
Tumor-targeted interleukin-12 synergizes with entinostat to overcome PD-1/PD-L1 blockade-resistant tumors harboring MHC-I and APM deficiencies
Journal for ImmunoTherapy of Cancer·2022· 43 citedOpen Access
Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication
Journal of Clinical Investigation·2022· 114 citedOpen Access
Abstract P034: Tumor-targeted interleukin-12 and Entinostat combination therapy improves cancer survival by reprogramming the tumor immune cell landscape
Cancer Immunology Research·2022
Entinostat and NHS-IL12 in aPD1/aPDL1 refractory models
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
Entinostat and NHS-IL12 in aPD1/aPDL1 refractory models
Zenodo (CERN European Organization for Nuclear Research)·2022Open Access
605 NHS-IL12 plus Entinostat combination effectively targets anti-PD-1/PD-L1 checkpoint resistant murine tumors harboring MHC Class I and antigen processing machinery deficiency
Regular and Young Investigator Award Abstracts·2021· 3 citedOpen Access
Tumour-targeted interleukin-12 and entinostat combination therapy improves cancer survival by reprogramming the tumour immune cell landscape
Nature Communications·2021· 83 citedOpen Access
Inactivated Plant Viruses as an Agrochemical Delivery Platform
ACS Agricultural Science & Technology·2021· 12 cited
<i>In situ</i>vaccine application of inactivated CPMV nanoparticles for cancer immunotherapy
Materials Advances·2021· 33 citedOpen Access
Plant Viruses and Bacteriophage-Based Reagents for Diagnosis and Therapy
Annual Review of Virology·2020· 40 citedOpen Access
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Frequent Co-authors

Nicole F. Steinmetz(15), Sofia R. Gameiro(10), Jeffrey Schlom(10), Christine M. Minnar(8), Kristin C. Hicks(6), Scott A. Hammond(6), Lucas A. Horn(4), Thomas J. Meyer(4), Margaret C. Cam(4), Claudia Palena(4), Jeremy Ratiu(4), Daniela M. Dinulescu(4), Simon J. Hollingsworth(4), Kristen Pollizzi(4), Reza A. Ghiladi(3), Sourabh Shukla(3), Veronique Beiss(3), Kanam Malhotra(3), Jun Ren(3), Chris M. Rands(3)