Andrew T. Placzek

Schrodinger (United States) — United States

Medicine · Health Sciences

10h-index480citations19works3.32yr avg
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Research Topics

Thyroid Disorders and Treatments(4), Neuroscience and Neuropharmacology Research(3), Chemical Synthesis and Analysis(3), Mosquito-borne diseases and control(2), Fluorine in Organic Chemistry(2)

Publications19 total

Accelerated <i>In Silico</i> Discovery of <b>SGR-1505</b> : A Potent MALT1 Allosteric Inhibitor for the Treatment of Mature B-Cell Malignancies
Journal of Medicinal Chemistry·2025· 5 cited
Abstract 4376: Preclinical characterization of SGR-4174, a potent and selective SOS1 inhibitor for the treatment of pan KRAS mutant cancers in combination with KRAS pathway inhibitors
Cancer Research·2025· 1 cited
Exploiting Solvent Exposed Salt-Bridge Interactions for the Discovery of Potent Inhibitors of SOS1 Using Free-Energy Perturbation Simulations
ACS Medicinal Chemistry Letters·2025· 4 cited
Emerging alphaviruses are sensitive to cellular states induced by a novel small-molecule agonist of the STING pathway
UNC Libraries·2020Open Access
4′‐Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of <scp>PKAN</scp>
EMBO Molecular Medicine·2019· 74 citedOpen Access
Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway
Journal of Virology·2017· 58 citedOpen Access
Inhibition of thyroid hormone receptor locally in the retina is a therapeutic strategy for retinal degeneration
The FASEB Journal·2017· 21 citedOpen Access
Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration
Bioorganic & Medicinal Chemistry·2017· 41 citedOpen Access
Elevated Serum Tetrac in Graves Disease: Potential Pathogenic Role in Thyroid-Associated Ophthalmopathy
The Journal of Clinical Endocrinology & Metabolism·2016· 14 citedOpen Access
Increasing Thyromimetic Potency through Halogen Substitution
ChemMedChem·2016· 9 citedOpen Access
Sobetirome prodrug esters with enhanced blood–brain barrier permeability
Bioorganic & Medicinal Chemistry·2016· 52 cited
New synthetic routes to thyroid hormone analogs: d6-sobetirome, 3H-sobetirome, and the antagonist NH-3
Tetrahedron·2015· 21 citedOpen Access
Synthesis of Frame-Shifted Farnesyl Diphosphate Analogs
Organic Letters·2012· 8 cited
New Synthetic Methodology for the Construction of 7-Substituted Farnesyl Diphosphate Analogs
Organic Letters·2011· 19 cited
Lipidomic metabolism analysis of the endogenous cannabinoid anandamide (N-arachidonylethanolamide)
Journal of Pharmaceutical and Biomedical Analysis·2010· 7 cited
Synthesis and biological evaluation of centrally modified farnesyl pyrophosphate analogs
Purdue e-Pubs (Purdue University System)·2009
Detection of nonsterol isoprenoids by HPLC–MS/MS
Analytical Biochemistry·2008· 63 cited
Scandium Triflate as an Efficient and Useful Catalyst for the Synthesis of β‐Amino Alcohols by Regioselective Ring Opening of Epoxides with Amines under Solvent‐Free Conditions.
ChemInform·2006· 1 cited
Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions
Tetrahedron Letters·2005· 82 cited

Frequent Co-authors

Thomas S. Scanlan(6), Richard A. Gibbs(3), Aaron Nilsen(3), Skylar J. Ferrara(3), James L. Donelson(2), Rushi Trivedi(2), Surya K. De(2), Richard A. Gibbs(2), Bryan Gall(2), Kara Pryke(2), Jinu Abraham(2), Nobuyo Mizuno(2), Sara Botto(2), Tina M. Sali(2), Rebecca M. Broeckel(2), Nicole N. Haese(2), Thomas E. Morrison(2), Mark T. Heise(2), Daniel N. Streblow(2), Victor R. DeFilippis(2)