Diana M. Downs

University of Georgia — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index4.3kcitations165works0.62yr avg
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Research Topics

Metabolism and Genetic Disorders(56), Biochemical and Molecular Research(53), Enzyme Structure and Function(49), Alcoholism and Thiamine Deficiency(43), Folate and B Vitamins Research(25)

Publications164 total

The XRE family protein DbuR is a transcriptional repressor of the <i>dbu</i> operon in <i>Pseudomonas putida</i>
Applied and Environmental Microbiology·2025Open Access
Biochemical and structural characterization of a reactive intermediate deaminase A homolog from Streptococcus sanguinis
Scientific Reports·2025Open Access
Perturbation of the MetJ regulon impacts the consequences of 2-aminoacrylate stress in Salmonella enterica
Microbiology·2025Open Access
Chemical proteomics enhances the understanding of 2AA stress in <i>Salmonella enterica</i>
mSystems·2025Open Access
Purine limitation prevents the exogenous pyridoxal 5′-phosphate accumulation of <i>Salmonella enterica yggS</i> mutants
Microbiology Spectrum·2024Open Access
Interpreting the role of antioxidants in vivo: A cautionary tale
Molecular Microbiology·2024Open Access
Tetrahydrofolate levels influence 2-aminoacrylate stress in <i>Salmonella enterica</i>
Journal of Bacteriology·2024· 2 citedOpen Access
Functional characterization of the <i>dbu</i> locus for D-branched-chain amino acid catabolism in <i>Pseudomonas putida</i>
Applied and Environmental Microbiology·2024· 3 citedOpen Access
RidA proteins contribute to fitness of S. enterica and E. coli by reducing 2AA stress and moderating flux to isoleucine biosynthesis
Microbial Cell·2024· 1 citedOpen Access
Modulators of a robust and efficient metabolism: Perspective and insights from the Rid superfamily of proteins
Advances in microbial physiology/Advances in Microbial Physiology·2023· 5 citedOpen Access
DadY (PA5303) is required for fitness of Pseudomonas aeruginosa when growth is dependent on alanine catabolism
Microbial Cell·2022· 6 citedOpen Access
The Cysteine Desulfurase IscS Is a Significant Target of 2-Aminoacrylate Damage in Pseudomonas aeruginosa
mBio·2022· 10 citedOpen Access
2-Aminoacrylate stress damages diverse PLP-dependent enzymes in vivo
Journal of Biological Chemistry·2022· 16 citedOpen Access
Genetic Analysis Using Vitamin B <sub>6</sub> Antagonist 4-Deoxypyridoxine Uncovers a Connection between Pyridoxal 5′-Phosphate and Coenzyme A Metabolism in Salmonella enterica
Journal of Bacteriology·2022· 3 citedOpen Access
Biochemical Genetics
Elsevier eBooks·2022
Crosstalk
Elsevier eBooks·2022· 1 cited
Pyridoxal and α-Ketoglutarate Independently Improve Function of Saccharomyces cerevisiae Thi5 in the Metabolic Network of Salmonella enterica
Journal of Bacteriology·2021· 2 citedOpen Access
Absence of <i>MMF1</i> disrupts heme biosynthesis by targeting Hem1pin <scp><i>Saccharomyces cerevisiae</i></scp>
Yeast·2021· 9 citedOpen Access
Loss of YggS (COG0325) impacts aspartate metabolism in <i>Salmonella enterica</i>
Molecular Microbiology·2021· 10 citedOpen Access
The Rid family member RutC of Escherichia coli is a 3-aminoacrylate deaminase
Journal of Biological Chemistry·2021· 7 citedOpen Access
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Frequent Co-authors

Jennifer A. Lambrecht(5), Elizabeth Skovran(5), Eric A. Webb(4), L A Petersen(4), Jeffrey M. Boyd(4), Jeffrey M. Flynn(3), N. Cecilia Martínez-Gómez(3), George E. Schmitz(3), Melissa R. Christopherson(3), Dustin C. Ernst(3), Tadhg P. Begley(2), Cynthia Kinsland(2), Jason J. Reddick(2), Kathy R. Claas(2), Thomas D. Niehaus(2), Kelsey Hodge‐Hanson(2), Arthur J.L. Cooper(2), Mona Elbadawi-Sidhu(2), Oliver Fiehn(2), Andrew D. Hanson(2)