Shunhai Wang

Regeneron (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index911citations66works3.02yr avg
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Research Topics

Protein purification and stability(34), Monoclonal and Polyclonal Antibodies Research(25), Viral Infectious Diseases and Gene Expression in Insects(13), Mass Spectrometry Techniques and Applications(12), Analytical Chemistry and Chromatography(9)

Publications66 total

Comprehensive forced degradation study revealing diverse chemical and physical degradation pathways of AAV8
Gene Therapy·2026Open Access
Insights into the structural differences between homo- and heterodimers enriched from a cocktail of monoclonal antibodies against SARS-CoV-2
Scientific Reports·2026Open Access
2025 White Paper on Recent Issues in Bioanalysis: What is the Future of Bioanalytical LIMS? AI/ML Integration in Bioanalysis; Tear Sample Collection; Radiolabeled Mass Balance Studies; Chiral Assays; Bioanalysis of Antibody-Oligonucleotide &amp; Bicycle Drug Conjugates ( <u>PART 1A</u> – Recommendations on Mass Spectrometry Assays, Chromatography, Sample Preparation and Regulated Bioanalysis Sampling, Validating, Analyzing &amp; Reporting <u>PART 1B</u> – Regulatory Agencies’ Input on Regulated Bioanalysis/BMV)
Bioanalysis·2025Open Access
Assessing the Impact of CDR Deamidation and Isomerization on mAb Target Binding Using Affinity-Resolved 2D-SEC-SCX-MS Analysis
Journal of the American Society for Mass Spectrometry·2025Open Access
Comprehensive Forced Degradation Study Revealing Diverse Chemical and Physical Degradation Pathways of AAV8
2025Open Access
An Online Buffer Exchange Platform for Charge Detection Mass Spectrometry Analysis of AAVs and AAV-Antibody Complexes
Journal of the American Society for Mass Spectrometry·2025Open Access
CDR clipping-induced heterodimerization: identification of a novel dimerization mechanism in a co-formulated antibody cocktail via a multifaceted mass spectrometry approach
mAbs·2025Open Access
The nonglycosylated variant in therapeutic monoclonal antibodies preferentially forms large aggregates under typical thermal stresses used in forced degradation studies
mAbs·2025· 2 citedOpen Access
Analytical strategies for identification and quantitation of heterodimers in co-formulated monoclonal antibody cocktails by native SEC-MS
Scientific Reports·2025Open Access
Online Coupling of Asymmetrical Flow Field-Flow Fractionation with Native Mass Spectrometry for Monoclonal Antibody Characterization
Journal of the American Society for Mass Spectrometry·2025· 1 citedOpen Access
A target affinity enrichment workflow to characterize critical post-translational modifications within therapeutic antibodies
Journal of Pharmaceutical Sciences·2025· 4 citedOpen Access
Simple endoglycosidase-assisted peptide mapping workflow for characterizing non-consensus n-glycosylation in therapeutic monoclonal antibodies
Journal of Pharmaceutical Sciences·2024· 2 cited
Development of a Novel Label-Free Subunit HILIC-MS Method for Domain-Specific Free Thiol Identification and Quantitation in Therapeutic Monoclonal Antibodies
Journal of the American Society for Mass Spectrometry·2024· 1 citedOpen Access
Characterization of adeno-associated virus capsid proteins using denaturing size-exclusion chromatography coupled with mass spectrometry
Journal of Pharmaceutical and Biomedical Analysis·2024· 6 citedOpen Access
Development of a Flow Through-Based Limited Digestion Approach for High-Throughput and High-Sequence Coverage Mapping of Therapeutic mRNAs
Analytical Chemistry·2024· 7 citedOpen Access
A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
Cell Reports Medicine·2024· 17 citedOpen Access
In-Depth Host Cell Protein Analysis and Viral Protein Impurity Monitoring in Adeno-Associated Virus-Based Gene Therapy Products Using Optimized Wide Window Data-Dependent Acquisition Method
Analytical Chemistry·2024· 1 cited
Distinct chemical degradation pathways of AAV1 and AAV8 under thermal stress conditions revealed by analytical anion exchange chromatography and LC-MS-based peptide mapping
Journal of Pharmaceutical and Biomedical Analysis·2024· 10 citedOpen Access
Affinity-Resolved Size Exclusion Chromatography Coupled to Mass Spectrometry: A Novel Tool to Study the Attribute-and-Function Relationship in Therapeutic Monoclonal Antibodies
Analytical Chemistry·2024· 7 citedOpen Access
An Online Native Mass Spectrometry Approach for Fast, Sensitive, and Quantitative Assessment of Adeno-Associated Virus Capsid Content Ratios
Journal of the American Society for Mass Spectrometry·2024· 7 citedOpen Access
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Frequent Co-authors

Yuetian Yan(27), Ning Li(16), Igor A. Kaltashov(13), Anita P. Liu(8), Ning Li(6), Cedric E. Bobst(5), Guanbo Wang(5), Tao Xing(5), Michael Rosconi(5), Tao Xing(4), Ning Li(4), Aynur Hermann(4), Zhengqi Zhang(4), Victoria C. Cotham(4), Shuli Tang(4), Thomas J. Daly(3), Dingjiang Liu(3), Mohammed Shameem(3), Gaoyuan Liu(3), Timothy N. Tiambeng(3)