Alfred Zimmerlin

Novartis (Switzerland) — Switzerland

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

22h-index2.6kcitations42works5.52yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(15), Analytical Chemistry and Chromatography(5), Synthesis and biological activity(4), Pesticide and Herbicide Environmental Studies(4), Melanoma and MAPK Pathways(4)

Publications42 total

A cereblon-based glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
Cell chemical biology·2025· 7 cited
A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
2024· 4 citedOpen Access
BET bromodomain inhibitors regulate keratinocyte plasticity
Nature Chemical Biology·2021· 13 cited
New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides
Chemical Research in Toxicology·2020· 27 cited
Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
Journal of Medicinal Chemistry·2020· 149 citedOpen Access
Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation
ACS Medicinal Chemistry Letters·2019· 21 citedOpen Access
Hoepfneretal NonAzoleERG11 AAC2012
2013
Fixing clearance as early as lead optimization using high throughput in vitro incubations in combination with exact mass detection and automatic structure elucidation of metabolites
Drug Discovery Today Technologies·2012· 4 cited
An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p
Antimicrobial Agents and Chemotherapy·2012· 21 citedOpen Access
Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase
Journal of Medicinal Chemistry·2011· 484 citedOpen Access
CYP3A Time-Dependent Inhibition Risk Assessment Validated with 400 Reference Drugs
Drug Metabolism and Disposition·2011· 90 cited
CYP4F Enzymes Are Responsible for the Elimination of Fingolimod (FTY720), a Novel Treatment of Relapsing Multiple Sclerosis
Drug Metabolism and Disposition·2010· 66 citedOpen Access
Metabolic Soft Spot Identification and Compound Optimization in Early Discovery Phases Using MetaSite and LC-MS/MS Validation
Journal of Medicinal Chemistry·2008· 116 cited
Evaluation of Fluorescence- and Mass Spectrometry–Based CYP Inhibition Assays for Use in Drug Discovery
SLAS DISCOVERY·2008· 45 citedOpen Access
High-throughput<i>in</i><i>vitro</i>profiling assays: lessons learnt from experiences at Novartis
Expert Opinion on Drug Metabolism & Toxicology·2006· 34 cited
PIMECROLIMUS: ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION IN HEALTHY VOLUNTEERS AFTER A SINGLE ORAL DOSE AND SUPPLEMENTARY INVESTIGATIONS IN VITRO
Drug Metabolism and Disposition·2006· 16 cited
A Locally Active Antiinflammatory Macrolide (MLD987) for Inhalation Therapy of Asthma
Journal of Medicinal Chemistry·2004· 17 citedOpen Access
SAR of 2,6‐Diamino‐3,5‐difluoropyridinyl Substituted Heterocycles as Novel p38 MAP Kinase Inhibitors
ChemInform·2002
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors
Bioorganic & Medicinal Chemistry Letters·2002· 56 citedOpen Access
Molecular identification and expression of the peroxidase responsible for the oxidative burst in French bean (Phaseolus vulgaris L.) and related members of the gene family
Plant Molecular Biology·2001· 94 cited
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Frequent Co-authors

G. Paul Bolwell(8), Francis Durst(8), Danièle Werck‐Reichhart(5), Láśzló Révész(5), Janet Dawson(4), Robert Pulz(4), Markus Trunzer(4), Yannick Batard(4), Franco E. Di Padova(4), Thomas Buhl(4), Roland Feifel(4), Hermann Gram(4), Peter Hiestand(4), Ute Manning(4), Bernard Faller(3), Markus Zollinger(3), Andreas Hofmann(3), Mathias Frederiksen(3), Michael Kiffe(3), Vito Guagnano(2)