Diana M. Norden

Integral Molecular (United States) — United States

Neuroscience · Life Sciences

16h-index2.9kcitations40works1.32yr avg
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Research Topics

Neuroinflammation and Neurodegeneration Mechanisms(17), Tryptophan and brain disorders(10), Monoclonal and Polyclonal Antibodies Research(6), Immune cells in cancer(6), Immune Response and Inflammation(5)

Publications40 total

29 A new approach methodology (NAM) for specificity testing: ISTAND qualification of the Membrane Proteome Array to evaluate off-target binding of MAb-based therapies
Regular and Young Investigator Award Abstracts·2025Open Access
991 Up to one-third of antibody drugs are nonspecific: a systematic evaluation of drugs throughout clinical and preclinical development
Regular and Young Investigator Award Abstracts·2025Open Access
Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine
Cell Reports·2025Open Access
Abstract 319: Testing of trispecific antibodies for treating multiple myeloma using the Membrane Proteome Array
Cancer Research·2025
Abstract 1161: A systematic evaluation of off-target binding in antibody-based biologics during clinical and preclinical development
Cancer Research·2025
1084 A systematic evaluation of off-target binding in antibody-based molecules during clinical and preclinical development
Regular and Young Investigator Award Abstracts·2024Open Access
The emergence of cell-based protein arrays to test for polyspecific off-target binding of antibody therapeutics
mAbs·2024· 9 citedOpen Access
1431 Developing an FDA-qualified drug development tool, the membrane proteome array, for specificity testing of antibodies and CAR-T cell therapies
Regular and Young Investigator Award Abstracts·2023· 1 citedOpen Access
Testing for Off-target Binding
2021· 1 cited
Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals
Molecules·2021· 17 citedOpen Access
Chronic spinal cord injury impairs primary CD8 T cell antiviral immunity but does not affect generation or function of memory CD8 T cells
Experimental Neurology·2019· 8 cited
Kistimonas alittae sp. nov., a gammaproteobacterium isolated from the marine annelid Alitta succinea
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY·2018· 10 cited
Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury
Journal of Neurotrauma·2018· 40 cited
Impaired CD8 T cell antiviral immunity following acute spinal cord injury
Journal of Neuroinflammation·2018· 24 citedOpen Access
Impaired CD8 T cell response to viral infection following acute spinal cord injury
The Journal of Immunology·2017
The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming
Journal of Neuroscience·2016· 135 citedOpen Access
Lumbar Myeloid Cell Trafficking into Locomotor Networks after Thoracic Spinal Cord Injury
Experimental Neurology·2016· 19 cited
619. AAV9 Transduction Is Similar in Adult and Aged Mouse Brains Following Intraparenchymal Injection
Molecular Therapy·2016· 1 citedOpen Access
Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain
Neurobiology of Aging·2016· 73 citedOpen Access
Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice
Life Sciences·2015· 43 cited
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Frequent Co-authors

Jonathan P. Godbout(22), Benjamin J. Doranz(7), Carmen Navia(6), Loren E. Wold(5), Donna O. McCarthy(5), Tabb Sullivan(5), Paige J. Trojanowski(4), Peter J. Reiser(4), John F. Sheridan(4), Rachel H. Fong(4), Elisa Navarro(3), Ashley M. Fenn(3), Sabahattin Bicer(3), Runfeng Jing(3), Daniel B. McKim(3), Raymond D. Devine(3), John R. Bethea(3), Jiu Jiang(3), Emmanuel Villanueva(2), Angela W. Corona(2)