Justyna Rak

Wellcome/MRC Cambridge Stem Cell Institute — United Kingdom

Medicine · Health Sciences

16h-index2.5kcitations46works8.22yr avg
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Research Topics

Acute Myeloid Leukemia Research(17), Hematopoietic Stem Cell Transplantation(9), Cancer Genomics and Diagnostics(6), Myeloproliferative Neoplasms: Diagnosis and Treatment(6), Prenatal Screening and Diagnostics(5)

Publications46 total

Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML.
Apollo (University of Cambridge)·2025Open Access
Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis
Nature Genetics·2025· 7 citedOpen Access
Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in <i>NPM1</i>-mutant AML
Blood·2025· 1 citedOpen Access
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein
Nature Biotechnology·2025· 16 citedOpen Access
Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Nature·2025· 25 citedOpen Access
<i>SF3B1</i> Mutations Promote Pervasive Metabolic Reprogramming and Enhanced Sensitivity to Glycolysis Inhibition
Blood·2024Open Access
<i>NPM1c</i> Mutations Are Associated with Reduced Levels of Multiple Ribosome Biogenesis Factors Leading to Therapeutic Vulnerabilities
Blood·2023Open Access
Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes
Cell Genomics·2023· 12 citedOpen Access
Different niches for stem cells carrying the same oncogenic driver affect pathogenesis and therapy response in myeloproliferative neoplasms
Nature Cancer·2023· 26 citedOpen Access
P1334: THE IMPACT OF SMALL MOLECULE INHIBITION OF METTL3 ON NORMAL HAEMATOPOIESIS
HemaSphere·2023Open Access
Ciclopirox ethanolamine preserves the immature state of human HSCs by mediating intracellular iron content
Blood Advances·2023· 2 citedOpen Access
Pharmacological inhibition of METTL3 impacts specific haematopoietic lineages
Leukemia·2023· 27 citedOpen Access
Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis
Science Advances·2022· 10 citedOpen Access
Different niches for mutant stem cells affect pathogenesis and therapy response in myeloproliferative neoplasms
2022· 1 citedOpen Access
The longitudinal dynamics and natural history of clonal haematopoiesis
Nature·2022· 331 citedOpen Access
2008 – INTEGRATIVE SINGLE-CELL ANALYSIS OF PRELEUKAEMIC MUTANT MOUSE MODELS ILLUSTRATES MUTATION-SPECIFIC HAEMATOPOIETIC PERTURBATIONS
Experimental Hematology·2022
The Longitudinal Dynamics and Natural History of Clonal Hematopoiesis
Blood·2021· 4 cited
Transcriptional variability accelerates pre-leukemia by cell diversification and perturbation of protein synthesis
2021Open Access
The longitudinal dynamics and natural history of clonal haematopoiesis
2021· 62 citedOpen Access
Uncoupling key determinants of hematopoietic stem cell engraftment through cell-specific and temporally controlled recipient conditioning
Stem Cell Reports·2021· 4 citedOpen Access
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Frequent Co-authors

George S. Vassiliou(16), Malgorzata Gozdecka(12), Nathalie Lambert(10), Aristi Damaskou(9), E. Joanna Baxter(9), Eliza Yankova(8), Konstantinos Tzelepis(8), Jean Roudier(8), George Giotopoulos(8), Doua F. Azzouz(7), Marielle Martin(7), Brian J.P. Huntly(7), Maria Eleftheriou(6), M. S. Vijayabaskar(6), Simón Méndez‐Ferrer(6), Margarete A. Fabre(5), Claudia Korn(5), Andrés García‐García(5), Nathalie Balandraud(5), Isabelle Auger(5)