David Bartkovitz

La Roche College — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

8h-index911citations11works0.02yr avg
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Research Topics

Microtubule and mitosis dynamics(4), Cancer-related Molecular Pathways(4), Regulation of Appetite and Obesity(3), Ubiquitin and proteasome pathways(3), Biochemical Analysis and Sensing Techniques(3)

Publications11 total

Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy
Bioorganic & Medicinal Chemistry·2014· 55 cited
Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development
ACS Medicinal Chemistry Letters·2013· 86 citedOpen Access
Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development
Journal of Medicinal Chemistry·2013· 583 citedOpen Access
Identification of novel, potent and selective inhibitors of Polo-like kinase 1
Bioorganic & Medicinal Chemistry Letters·2011· 33 cited
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity
Journal of Medicinal Chemistry·2006· 116 citedOpen Access
CCDC 283241: Experimental Crystal Structure Determination
The Cambridge Structural Database·2006Open Access
Preparation of human Melanocortin-4 receptor agonist libraries: Linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2
Bioorganic & Medicinal Chemistry Letters·2005· 8 citedOpen Access
Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides
Bioorganic & Medicinal Chemistry Letters·2005· 16 citedOpen Access
Highly Selective Cyclic Peptides for Human Melanocortin-4 Receptor (MC-4 R): Design, Synthesis, Bioactive Conformation, and Pharmacological Evaluation as an Anti-Obesity Agent
2001· 4 cited
ChemInform Abstract: A Facile and General Synthesis of 3‐(Acyloxy)cephalosporins.
ChemInform·1992
A facile and general synthesis of 3-(acyloxy)cephalosporins
The Journal of Organic Chemistry·1992· 10 cited

Frequent Co-authors

Xin‐Jie Chu(8), Qingjie Ding(4), Nan Jiang(4), Kathryn Packman(4), Bradford Graves(4), Waleed Danho(4), Joseph Swistok(4), Grazyna Kurylko(4), Lida Qi(4), Keith A. Yagaloff(4), Zhuming Zhang(3), Jinjun Liu(3), Christian Tovar(3), Zoran Filipovic(3), Brian Higgins(3), Kelli Glenn(3), Lyubomir T. Vassilev(3), Li Chen(3), Cheryl A. Janson(2), Yingsi Chen(2)