Yingsi Chen

Southern Medical University — China

Medicine · Health Sciences

10h-index473citations14works4.02yr avg
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Research Topics

Cancer-related Molecular Pathways(5), Microtubule and mitosis dynamics(4), Cancer, Hypoxia, and Metabolism(3), Cancer Mechanisms and Therapy(3), Angiogenesis and VEGF in Cancer(2)

Publications14 total

Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity
Ecotoxicology and Environmental Safety·2024· 4 citedOpen Access
Hyperoside attenuates Cd-induced kidney injury via inhibiting NLRP3 inflammasome activation and ROS/MAPK/NF-κB signaling pathway in vivo and in vitro
Food and Chemical Toxicology·2023· 27 cited
Identification of novel, potent and selective inhibitors of Polo-like kinase 1
Bioorganic & Medicinal Chemistry Letters·2011· 33 cited
Discovery and optimization of 2-phenyloxazole derivatives as diacylglycerol acyltransferase-1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 16 citedOpen Access
Discovery of Orally Active Carboxylic Acid Derivatives of 2-Phenyl-5-trifluoromethyloxazole-4-carboxamide as Potent Diacylglycerol Acyltransferase-1 Inhibitors for the Potential Treatment of Obesity and Diabetes
Journal of Medicinal Chemistry·2011· 41 citedOpen Access
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 54 citedOpen Access
<i>In vitro</i> and <i>in vivo</i> activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials
Molecular Cancer Therapeutics·2006· 102 citedOpen Access
Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), A Potent and Selective Cyclin-Dependent Kinase Inhibitor with Significant in Vivo Antitumor Activity
Journal of Medicinal Chemistry·2006· 116 citedOpen Access
Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis
Bioorganic & Medicinal Chemistry Letters·2006· 10 citedOpen Access
RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: Synthesis and biological evaluation
Bioorganic & Medicinal Chemistry·2005· 21 citedOpen Access
Design, synthesis of 1,4-cyclohexyldiamine substituted diaminopyrimidines as selective inhibitors of CDK1, CDK2 and CDK4 and their in vitro and in vivo evaluation
Cancer Research·2005· 1 cited
3,5,6-Trisubstituted naphthostyrils as CDK2 inhibitors
Bioorganic & Medicinal Chemistry Letters·2003· 29 citedOpen Access
SAR of Melanin-concentration Hormone (MCH), an Important Regulatory Hormone in Feeding Behavior
2001
Purification and Characterization of Human α-Galactosidase A Expressed in Insect Cells Using a Baculovirus Vector
Protein Expression and Purification·2000· 19 cited

Frequent Co-authors

Wanda DePinto(4), Xuefeng Yin(4), Melissa Smith(4), Tom Nevins(4), Kin‐Chun Luk(4), Xin‐Jie Chu(3), Kathryn Packman(3), Christine Lukacs(3), Qing Xiang(3), Allen Lovey(3), Kenneth Kolinsky(3), Fred Konzelmann(3), Lee McDermott(3), Mary Ellen Simcox(3), David Bartkovitz(2), Sung-Sau So(2), Binh Thanh Vu(2), Qingjie Ding(2), Nan Jiang(2), Petra Goelzer(2)