James Posada

Resolve Therapeutics (United States) — United States

Medicine · Health Sciences

19h-index2.8kcitations31works9.52yr avg
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Research Topics

Systemic Lupus Erythematosus Research(6), Nitric Oxide and Endothelin Effects(5), Protein Kinase Regulation and GTPase Signaling(5), Genetics, Aging, and Longevity in Model Organisms(5), Reproductive Biology and Fertility(4)

Publications31 total

Assessment of the Impact of RNase in Patients With Severe Fatigue Related to Post-Acute Sequelae of SARS-CoV-2 Infection: A Randomized Phase 2 Trial of RSLV-132
Clinical Infectious Diseases·2024· 6 citedOpen Access
Evaluation of RNase therapy in systemic lupus erythematosus: a randomised phase 2a clinical trial of RSLV-132
Lupus Science & Medicine·2024· 13 citedOpen Access
Reply
Arthritis & Rheumatology·2020
Improvement of Severe Fatigue Following Nuclease Therapy in Patients With Primary Sjögren’s Syndrome: A Randomized Clinical Trial
Arthritis & Rheumatology·2020· 58 citedOpen Access
OP0202 EFFECT OF RSLV-132 ON FATIGUE IN PATIENTS WITH PRIMARY SJÖGREN'S SYNDROME – RESULTS OF A PHASE II RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PROOF OF CONCEPT STUDY
Annals of the Rheumatic Diseases·2019· 12 citedOpen Access
Safety, pharmacokinetics, and pharmacodynamics of RSLV-132, an RNase-Fc fusion protein in systemic lupus erythematosus: a randomized, double-blind, placebo-controlled study
Lupus·2016· 41 cited
Blood-Borne RNA Correlates with Disease Activity and IFN-Stimulated Gene Expression in Systemic Lupus Erythematosus
The Journal of Immunology·2016· 19 cited
OP0186 Immune Complex Bound U1 and Y1 RNA Correlates with Interferon-Stimulated Gene Expression and Disease Activity: An Observational Study of Sysytemic Lupus Erythematosus Patients
Annals of the Rheumatic Diseases·2016
THU0293 Safety, Pharmacokinetics, Enzyme Activity, and Immunogenicity of RSLV-132, A Novel Rnase Fusion Protein Developed To Reduce RNA-Containing Immune Complexes in Systemic Lupus Erythematosus
Annals of the Rheumatic Diseases·2016· 1 cited
Transmembrane Helix 7 of the Endothelin B Receptor Regulates Downstream Signaling
Journal of Biological Chemistry·1999· 10 citedOpen Access
Endothelin-Stimulated ERK Activation in Airway Smooth-Muscle Cells Requires Calcium Influx and Raf Activation
American Journal of Respiratory Cell and Molecular Biology·1999· 28 cited
Map Kinases in Airway Disease: Standing at the Confluence of Basic and Clinical Science
1998
Activation of ERK and JNK1 MAP kinases in cultured lung tissue
American Journal of Physiology-Lung Cellular and Molecular Physiology·1997· 9 cited
Inhibition of ERK activation attenuates endothelin-stimulated airway smooth muscle cell proliferation.
American Journal of Respiratory Cell and Molecular Biology·1997· 79 cited
Activation of Multiple Mitogen-activated Protein Kinase Signal Transduction Pathways by the Endothelin B Receptor Requires the Cytoplasmic Tail
Journal of Biological Chemistry·1996· 49 citedOpen Access
Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor.
PubMed·1996· 231 cited
JNK, but not MAPK, activation is associated with Fas‐mediated apoptosis in human T cells
European Journal of Immunology·1996· 141 cited
The Seven-transmembrane-spanning Receptors for Endothelin and Thrombin Cause Proliferation of Airway Smooth Muscle Cells and Activation of the Extracellular Regulated Kinase and c-Jun NH2-terminal Kinase Groups of Mitogen-activated Protein Kinases
Journal of Biological Chemistry·1996· 112 citedOpen Access
[30] Genetic and biochemical analysis of Cdc42p function in Saccharomyces cerevisiae and Schizosaccharomyces pombe
Methods in enzymology on CD-ROM/Methods in enzymology·1995· 1 cited
p42 mitogen-activated protein kinase in brain: Prominent localization in neuronal cell bodies and dendrites
Neuroscience·1993· 158 cited
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Frequent Co-authors

Jonathan A. Cooper(8), Daniel Burge(7), Paul Vichi(4), Alyn Whelchel(4), Natalie G. Ahn(3), Steven Pelech(3), John N. Evans(3), Benjamin A. Fisher(3), Wan‐Fai Ng(3), Alan Kivitz(3), Richard W. Martin(3), John R. Doedens(3), Keith B. Elkon(3), Nelson S. Yew(2), George F. Vande Woude(2), T R Tritton(2), Ruedi Aebersold(2), Paul Shapiro(2), Thomas R. Tritton(2), Jessica Tarn(2)