Shay Karkashon

Albert Einstein College of Medicine — United States

Neuroscience · Life Sciences

6h-index349citations19works0.02yr avg
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Research Topics

Tryptophan and brain disorders(9), Hemoglobinopathies and Related Disorders(6), Bipolar Disorder and Treatment(5), Erythrocyte Function and Pathophysiology(4), Prenatal Screening and Diagnostics(3)

Publications19 total

Characterization of the structural determinants of the ubiquitin-dependent proteasomal degradation of human hepatic tryptophan 2,3-dioxygenase
Biochemical Journal·2021· 3 citedOpen Access
Human hepatic tryptophan 2,3-dioxygenase ubiquitin-dependent protein degradation: The critical role of its exosite as the molecular lynchpin of its substrate-mediated protein stabilization
2019· 1 citedOpen Access
Crystal structure of human indoleamime 2,3-dioxygenase (IDO1) in complex with L-Trp and cyanide, Northeast Structural Genomics Target HR6160
2018
Inhibition Mechanisms of Human Indoleamine 2,3 Dioxygenase 1
Journal of the American Chemical Society·2018· 42 citedOpen Access
Structure of the S167H mutant of human indoleamine 2,3 dioxygenase in complex with tryptophan and cyanide
2018
Structural insights into substrate and inhibitor binding sites in human indoleamine 2,3-dioxygenase 1
Nature Communications·2017· 158 citedOpen Access
Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase
Scientific Reports·2016· 96 citedOpen Access
Crystal structure of human TDO in complex with Trp and dioxygen, Northeast Structural Genomics Consortium Target HR6161
2016
Structural determinants of human tryptophan 2,3‐dioxygenase (TDO) protein degradation
The FASEB Journal·2016
Intermediaries of branched chain amino acid metabolism induce fetal hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells
Blood Cells Molecules and Diseases·2015· 6 cited
Allosteric Regulation of Redox Potential and Enzyme Activity of Tryptophan Dioxygenase
ECS Meeting Abstracts·2014· 1 cited
The Inhibitory Substrate Binding Site of Human Indoleamine 2,3-Dioxygenase
Biophysical Journal·2013Open Access
Comparative Studies of Human Indoleamine 2,3-Dioxygenase (IDO) and Tryptophan Dioxygenase (TDO)
Biophysical Journal·2012Open Access
Induction of fetal/embryonic globin gene expression depends on intact cell signaling in definitive erythroid cells
Blood Cells Molecules and Diseases·2010
Butyrate Downregulates the Expression of a Number of Repressors of Fetal Hemoglobin In Definitive Erythroid Cells
Blood·2010· 1 cited
Short Chain Fatty Acids and p38 in the Induction of Embryonic/Fetal Globin Genes During Definitive Erythropoiesis.
Blood·2009
Short-chain fatty acid–mediated effects on erythropoiesis in primary definitive erythroid cells
Blood·2009· 17 citedOpen Access
A Novel Model of Short Chain Fatty Acid (SCFA)- Mediated up-Regulation of Embryonic/Fetal Globin Genes during Definitive Erythropoiesis.
Blood·2008
tRNase Z Catalysis and Conserved Residues on the Carboxy Side of the His Cluster
Biochemistry·2007· 24 citedOpen Access

Frequent Co-authors

Ariel Lewis-Ballester(11), Syun‐Ru Yeh(11), Jane A. Little(6), Himanshu Bhatia(5), Amrita Dutta(5), Dipanwita Batabyal(4), Maria Almira Correia(4), T.L. Poulos(3), F. Forouhar(3), J. Seetharaman(3), Radha Raghupathy(3), Sung-Mi Kim(2), Scott Lew(2), Yongqiang Wang(2), M. Hussain(2), Liang Tong(2), Jennifer L. Hallock(2), Ann Dean(2), Yi Liu(2), Sung‐Mi Kim(2)