Marianne M. Lee

Chinese University of Hong Kong — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index832citations32works2.12yr avg
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Research Topics

Enzyme Catalysis and Immobilization(5), RNA and protein synthesis mechanisms(4), RNA Interference and Gene Delivery(4), Click Chemistry and Applications(4), Genomics and Phylogenetic Studies(3)

Publications32 total

An engineered yeast cytosine deaminase with improved catalytic activity and stability for macrophage-mediated enzyme/prodrug therapy
Communications Biology·2025Open Access
A Simple Strategy for Co‐Immobilization of NADH‐Dependent Enzymes and NADH for Efficient Biocatalysis in Continuous Flow Reactors
ChemSusChem·2025· 2 citedOpen Access
Gene delivery of SUMO1-derived peptide rescues neuronal degeneration and motor deficits in a mouse model of Parkinson’s disease
Molecular Therapy·2025· 2 cited
Site-specific <i>in vivo</i> protein SUMOylation <i>via</i> translational incorporation of a proximity-reactive pyrrolysine analogue
RSC Chemical Biology·2025Open Access
A Targeted and Protease-Activated Genetically Encoded Melittin-Containing Particle for the Treatment of Cutaneous and Visceral Leishmaniasis
ACS Applied Materials & Interfaces·2024· 2 citedOpen Access
Mechanoresponsive Protein Crystals for NADH Recycling in Multicycle Enzyme Reactions
Journal of the American Chemical Society·2024· 7 citedOpen Access
Genetically Encoded Multienzyme Particles for the Biosynthesis of Putrescine from <scp>l</scp>-Arginine
ACS Sustainable Chemistry & Engineering·2024· 2 citedOpen Access
A Bioresponsive Genetically Encoded Antimicrobial Crystal for the Oral Treatment of <i>Helicobacter Pylori</i> Infection
Advanced Science·2023· 8 citedOpen Access
Pyrrolysine-Inspired in Cellulo Synthesis of an Unnatural Amino Acid for Facile Macrocyclization of Proteins
Journal of the American Chemical Society·2023· 13 citedOpen Access
Insights from the Structure of an Active Form of Bacillus thuringiensis Cry5B
Toxins·2022· 6 citedOpen Access
Restoration of p53 activity via intracellular protein delivery sensitizes triple negative breast cancer to anti-PD-1 immunotherapy
Journal for ImmunoTherapy of Cancer·2022· 32 citedOpen Access
Cytosolic delivery of CDK4/6 inhibitor p16 protein using engineered protein crystals for cancer therapy
Acta Biomaterialia·2021· 6 cited
Amine-Linked Flavonoids as Agents against Cutaneous Leishmaniasis
Antimicrobial Agents and Chemotherapy·2021· 7 citedOpen Access
A SUMO1-Derived Peptide Targeting SUMO-Interacting Motif Inhibits α-Synuclein Aggregation
Cell chemical biology·2021· 29 cited
Efficient encapsulation of functional proteins into erythrocytes by controlled shear-mediated membrane deformation
Lab on a Chip·2021· 5 cited
<i>In Vivo</i> Enzyme Entrapment in a Protein Crystal
Journal of the American Chemical Society·2020· 54 cited
Directed evolution of a genetically encoded immobilized lipase for the efficient production of biodiesel from waste cooking oil
Biotechnology for Biofuels·2019· 57 citedOpen Access
Cry Protein Crystal-Immobilized Metallothioneins for Bioremediation of Heavy Metals from Water
Crystals·2019· 14 citedOpen Access
Direct production of a genetically-encoded immobilized biodiesel catalyst
Scientific Reports·2018· 43 citedOpen Access
The pesticidal Cry6Aa toxin from Bacillus thuringiensis is structurally similar to HlyE-family alpha pore-forming toxins
BMC Biology·2016· 50 citedOpen Access
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Frequent Co-authors

Michael K. Chan(31), Bradley S. Heater(6), Zaofeng Yang(6), Tomasz Fekner(4), Jiale Zheng(4), Xu Xiong(3), Sunney I. Chan(2), Yu‐Jhang Lu(2), Penumaka Nagababu(2), Suman Maji(2), Mu‐Cheng Hung(2), I‐Jui Hsu(2), Pham Dinh Minh(2), Jeff C.‐H. Lai(2), Kok Yoah Ng(2), Sridevi Ramalingam(2), Steve S.‐F. Yu(2), Xin Li(2), Wai Shan Chan(2), Ralf Bundschuh(2)