Stephen H. Leppla

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

88h-index23.3kcitations384works1.12yr avg
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Research Topics

Bacillus and Francisella bacterial research(301), Bacterial Genetics and Biotechnology(143), Microbial Inactivation Methods(81), Bacteriophages and microbial interactions(73), Toxin Mechanisms and Immunotoxins(52)

Publications381 total

Structural basis of double-stranded RNA recognition by the J2 monoclonal antibody
Nature Communications·2025Open Access
Environmental regulation of toxin production in Bacillus anthracis
PLoS Pathogens·2025· 1 citedOpen Access
Environmental Regulation of Toxin Production in <i>Bacillus anthracis</i>
2025· 1 citedOpen Access
Anthrax ET activates Rac1 and RTK signaling to induce F-actin reorganization and endothelial permeability
iScience·2025Open Access
Targeting virulence to disarm the pathogen: Enzyme-activated-substrate inhibition of Anthrax edema factor
Bioorganic & Medicinal Chemistry Letters·2025Open Access
A novel AAA+ ATPase required for sporulation and stress response in <i>Bacillus anthracis</i>
2025Open Access
Specificity and mechanism of the double-stranded RNA-specific J2 monoclonal antibody
2025· 4 citedOpen Access
ATP depletion in anthrax edema toxin pathogenesis
PLoS Pathogens·2025· 3 citedOpen Access
ERK pathway reactivation prevents anthrax toxin lethality in mice
Nature Microbiology·2025· 4 cited
Targeting Virulence to Disarm the Pathogen: Enzyme-Activated-Substrate Inhibition of Anthrax Edema Factor
SSRN Electronic Journal·2025Open Access
Anthrax lethal factor
Handbook of Proteolytic Enzymes·2025
Anthrax lethal toxin exerts potent metabolic inhibition of the cardiovascular system
mBio·2024· 3 citedOpen Access
Targeting canine mammary neoplastic epithelial cells with a reengineered anthrax toxin: first study
Veterinary Research Communications·2024· 1 citedOpen Access
Abstract 1498 Environmental Regulation of Toxin Production in Bacillus Anthracis
Journal of Biological Chemistry·2024Open Access
S9.6-based hybrid capture immunoassay for pathogen detection
Scientific Reports·2023· 6 citedOpen Access
S9.6-based hybrid capture immunoassay for pathogen detection
Research Square (Research Square)·2023Open Access
Structural basis of dsRNA recognition by the J2 monoclonal antibody
Acta Crystallographica Section A Foundations and Advances·2023Open Access
S9.6 Antibody–Enzyme Conjugates for the Detection of DNA–RNA Hybrids
Bioconjugate Chemistry·2023· 11 citedOpen Access
Data from Matrix Metalloproteinase–Activated Anthrax Lethal Toxin Inhibits Endothelial Invasion and Neovasculature Formation during &lt;i&gt;In vitro&lt;/i&gt; Morphogenesis
2023Open Access
Supplementary Figures S1-S3 from Matrix Metalloproteinase–Activated Anthrax Lethal Toxin Inhibits Endothelial Invasion and Neovasculature Formation during &lt;i&gt;In vitro&lt;/i&gt; Morphogenesis
2023Open Access
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Frequent Co-authors

Mahtab Moayeri(12), Shihui Liu(9), Kurt R. Klimpel(7), V M Gordon(4), Robert Liddington(4), Laurence Abrami(4), Gijs R. van den Brink(4), R. John Collier(3), Naveen Arora(3), Devorah Crown(3), Yogendra Singh(3), Carlo Petosa(2), Gary Thomas(2), Tien Yin Wong(2), Robert Schwarzenbacher(2), Sukjoon Park(2), Gezahegn Gorfu(2), Kimberly M. Cirelli(2), Jeroen P. J. Saeij(2), Michael E. Grigg(2)