David J. Hardee

AbbVie (United States) — United States

Chemistry · Physical Sciences

8h-index1.4kcitations23works0.02yr avg
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Research Topics

Cyclopropane Reaction Mechanisms(8), Crystallization and Solubility Studies(4), X-ray Diffraction in Crystallography(4), Organometallic Complex Synthesis and Catalysis(3), Synthetic Organic Chemistry Methods(3)

Publications23 total

Structure-Guided Design of Potent and Selective Covalent Inhibitors Targeting the SARS-CoV-2 Papain-like Protease
Journal of Medicinal Chemistry·2026
Academic–Industrial Collaboration in Synthesis with Real-Time Impact in Medicinal Chemistry: Discovery of Cystic Fibrosis C2 Corrector ABBV-602
ACS Medicinal Chemistry Letters·2025Open Access
X- ray crystallography reveals the mechanism of SARS-CoV-2 PLpro dimerization mediated by a DNA-encoded library screening hit
Structural Dynamics·2025Open Access
A new corrector rescues F508del-CFTR folding through stabilization of the TMD1-NBD1 linker
2025Open Access
Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712
Journal of Medicinal Chemistry·2023· 9 citedOpen Access
Antiviral Drug Discovery for the Treatment of COVID-19 Infections
Viruses·2022· 97 citedOpen Access
CCDC 2071127: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
CCDC 2071154: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
CCDC 2071667: Experimental Crystal Structure Determination
The Cambridge Structural Database·2021Open Access
Role of Additives to Overcome Limitations of Intermolecular Rhodium-Catalyzed Asymmetric Cyclopropanation
2021· 6 citedOpen Access
Role of Additives to Overcome Limitations of Intermolecular Rhodium-Catalyzed Asymmetric Cyclopropanation
2021Open Access
Asymmetric synthesis of pharmaceutically relevant 1-aryl-2-heteroaryl- and 1,2-diheteroarylcyclopropane-1-carboxylates
Chemical Science·2021· 42 citedOpen Access
Activation of Electron‐Deficient Quinones through Hydrogen‐Bond‐Donor‐Coupled Electron Transfer
Angewandte Chemie·2015· 21 citedOpen Access
Activation of Electron‐Deficient Quinones through Hydrogen‐Bond‐Donor‐Coupled Electron Transfer
Angewandte Chemie International Edition·2015· 61 citedOpen Access
Alkaline quinone flow battery
Science·2015· 1.1k citedOpen Access
Title: Alkaline Quinone Flow Battery
2015
Part 1: Lanthanum(III) Triflate-Catalyzed Cyclopropanation via Intramolecular Methylene Transfer. Part 2: Reaction Design with Aromatic Ions - Nucleophilic Acyl Substitution and Organophotoredox Catalysts
Columbia Academic Commons (Columbia University)·2011Open Access
ChemInform Abstract: Nucleophilic Acyl Substitution via Aromatic Cation Activation of Carboxylic Acids: Rapid Generation of Acid Chlorides under Mild Conditions.
ChemInform·2010
Nucleophilic Acyl Substitution via Aromatic Cation Activation of Carboxylic Acids: Rapid Generation of Acid Chlorides under Mild Conditions
Journal of the American Chemical Society·2010· 86 cited
CCDC 744911: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
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Frequent Co-authors

Timothy R. Hodges(8), Jack C. Sharland(7), Eric A. Voight(7), Huw M. L. Davies(6), Tristan H. Lambert(5), Wei Gong(5), Michael R. Schrimpf(4), Bo Wei(3), Kaixiang Lin(2), Qing Chen(2), Michael R. Gerhardt(2), Liuchuan Tong(2), Louise Eisenach(2), Alvaro W. Valle(2), Roy G. Gordon(2), Michael J. Aziz(2), Michael P. Marshak(2), Teresa I. Ng(2), Lyudmila Kovalchuke(2), Amanda K. Turek(2)