Flavie Lesept

The Lymphoma Academic Research Organisation — France

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index741citations27works5.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(9), Neuroinflammation and Neurodegeneration Mechanisms(7), Neuroscience and Neuropharmacology Research(6), Acute Ischemic Stroke Management(6), Blood Coagulation and Thrombosis Mechanisms(4)

Publications27 total

Abstract DP347: LYS241: A Novel Humanized Antibody Counteracting tPA-Mediated Neurotoxicity and BBB Disruption in Stroke
Stroke·2026
Spatial and Temporal Single-Cell Profiling of RNA Compartmentalization in Neurons with Nanotweezers
ACS Nano·2025· 5 citedOpen Access
The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity
Journal of Neuroinflammation·2025· 5 citedOpen Access
Improving stroke outcomes in hyperglycemic mice by modulating tPA/NMDAR signaling to reduce inflammation and hemorrhages
Blood Advances·2024· 10 citedOpen Access
Physics-Based Deep Learning for Imaging Neuronal Activity via Two-Photon and Light Field Microscopy
IEEE Transactions on Computational Imaging·2023· 7 cited
Physics-based Deep Learning for Imaging Neuronal Activity via Two-photon and Light Field Microscopy
2022Open Access
Targeting NMDA Receptors at the Neurovascular Unit: Past and Future Treatments for Central Nervous System Diseases
International Journal of Molecular Sciences·2022· 34 citedOpen Access
Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization
Science Signaling·2022· 12 cited
DISC1 Regulates Mitochondrial Trafficking in a Miro1-GTP-Dependent Manner
Frontiers in Cell and Developmental Biology·2020· 27 citedOpen Access
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome
Figshare·2020Open Access
The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C
Journal of Cell Science·2019· 57 citedOpen Access
SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling
Cell Reports·2019· 30 citedOpen Access
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome
Autophagy·2019· 81 citedOpen Access
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome
Figshare·2019Open Access
Axonal autophagosome maturation defect through failure of ATG9A sorting underpins pathology in AP-4 deficiency syndrome
Figshare·2019Open Access
Tissue-Type Plasminogen Activator Controlled Corticogenesis Through a Mechanism Dependent of NMDA Receptors Expressed on Radial Glial Cells
Cerebral Cortex·2018· 23 cited
Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors
Cell Death and Disease·2016· 50 citedOpen Access
Neuroendothelial NMDA receptors as therapeutic targets in experimental autoimmune encephalomyelitis
Brain·2016· 50 citedOpen Access
The story of an exceptional serine protease, tissue-type plasminogen activator (tPA)
Revue Neurologique·2015· 43 cited
Impacts of tissue-type plasminogen activator (tPA) on neuronal survival
Frontiers in Cellular Neuroscience·2015· 76 citedOpen Access
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Frequent Co-authors

Denis Vivien(14), Josef T. Kittler(11), Eric Maubert(6), Carine Ali(5), Davor Ivankovic(4), James Drew(4), Ian J. White(4), Guillermo López‐Doménech(4), Sharon A. Tooze(4), Arnaud Chevilley(4), Axel Montagne(4), Cyrille Orset(4), Thomas Bertrand(4), Richard Macrez(4), Manuel Blanc(4), Sophie Lenoir(3), Isabelle Bardou(3), Yannick Hommet(3), Morgane Louessard(3), Amandine Jullienne(3)