Wolfgang Froestl

AC Immune (Switzerland) — Switzerland

Neuroscience · Life Sciences

47h-index9.7kcitations142works0.02yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(81), Neurotransmitter Receptor Influence on Behavior(36), Nicotinic Acetylcholine Receptors Study(29), Receptor Mechanisms and Signaling(22), Biochemical Analysis and Sensing Techniques(14)

Publications142 total

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer’s disease
Bioorganic & Medicinal Chemistry Letters·2017· 23 citedOpen Access
Synthesis and structure–activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of β-amyloid-42 aggregation
Bioorganic & Medicinal Chemistry Letters·2016· 16 citedOpen Access
Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-Modifying Drugs. Update 2014
Journal of Alzheimer s Disease·2014· 8 citedOpen Access
Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. Update 2014
Journal of Alzheimer s Disease·2014· 25 citedOpen Access
Cognitive Enhancers (Nootropics). Part 1: Drugs interacting with Receptors. Update 2014
Journal of Alzheimer s Disease·2014· 27 citedOpen Access
Increased Efflux of Amyloid-β Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis
Journal of Alzheimer s Disease·2013· 13 citedOpen Access
P4–316: Visualization of beta‐amyloid plaque reduction by small‐molecule beta‐amyloid oligomer aggregation inhibitors in hAPPSL transgenic mice
Alzheimer s & Dementia·2013
Cognitive Enhancers (Nootropics). Part 3: Drugs Interacting with Targets other than Receptors or Enzymes. Disease-modifying Drugs
Journal of Alzheimer s Disease·2013· 29 citedOpen Access
Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes
Journal of Alzheimer s Disease·2013· 32 citedOpen Access
Antidepressant-like activity of CGP 36742 and CGP 51176
2013
Cognitive Enhancers (Nootropics). Part 1: Drugs Interacting with Receptors
Journal of Alzheimer s Disease·2012· 90 cited
Discovery and Structure Activity Relationship of Small Molecule Inhibitors of Toxic β-Amyloid-42 Fibril Formation
Journal of Biological Chemistry·2012· 58 citedOpen Access
P1‐338: Comparison of toxic beta‐amyloid oligomer inhibitors for rescuing memory deficits in APP transgenic mice
Alzheimer s & Dementia·2012
The Development of Medications for Alcohol-Use Disorders Targeting the GABAB Receptor System
Recent Patents on CNS Drug Discovery·2012· 20 cited
6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2011· 22 cited
The GABA<sub>B</sub>receptor agonist CGP44532 and the positive modulator GS39783 reverse some behavioural changes related to positive syndromes of psychosis in mice
British Journal of Pharmacology·2011· 30 citedOpen Access
An Historical Perspective on Gabaergic Drugs
Future Medicinal Chemistry·2011· 83 cited
Both GABAB receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats
European Journal of Pharmacology·2011· 27 cited
Activation of the GABAB Receptor Prevents Nicotine-Induced Locomotor Stimulation in Mice
Frontiers in Psychiatry·2011· 21 citedOpen Access
Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats
Psychopharmacology·2010· 52 citedOpen Access
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Frequent Co-authors

Klemens Kaupmann(18), Bernhard Bettler(14), Johannes Mosbacher(11), Jakob Heid(10), Stuart J. Mickel(6), H. Bittiger(6), Valérie Schuler(5), John F. Cryan(5), Jean‐Philippe Pin(5), Mauro A.M. Carai(5), Gian Luigi Gessa(5), Giancarlo Colombo(5), Barbara Malitschek(4), Serge Bischoff(4), Gilles Sansig(4), Mario F. Pozza(4), Herman van der Putten(4), Cédric Mombereau(4), Hans-Rudolf Olpe(4), Felix Brugger(4)