Nicola Solaroli

Karolinska Institutet — Sweden

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index846citations36works0.02yr avg
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Research Topics

Biochemical and Molecular Research(16), Chronic Lymphocytic Leukemia Research(8), Mitochondrial Function and Pathology(4), Cancer-related Molecular Pathways(4), HIV/AIDS drug development and treatment(3)

Publications36 total

The many isoforms of human adenylate kinases
The International Journal of Biochemistry & Cell Biology·2014· 159 cited
Late-onset respiratory failure due to <i>TK2</i> mutations causing multiple mtDNA deletions
Neurology·2013· 24 citedOpen Access
The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase
The International Journal of Biochemistry & Cell Biology·2013· 56 cited
The residual deoxycytidine phosphorylating activity of thymidine kinase 2 may determine differences in clinical manifestations of thymidine kinase 2 deficiency
Mitochondrion·2012
Design, synthesis and biological evaluation of 2′-deoxy-2′,2′-difluoro-5-halouridine phosphoramidate ProTides
Bioorganic & Medicinal Chemistry·2011· 13 citedOpen Access
Synthesis, modeling and evaluation of 3′-(1-aryl-1H-tetrazol-5-ylamino)-substituted 3′-deoxythymidine derivatives as potent and selective human mitochondrial thymidine kinase inhibitors
Organic & Biomolecular Chemistry·2010· 16 citedOpen Access
The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes
Biochemical Journal·2010· 44 citedOpen Access
Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome
Journal of Inherited Metabolic Disease·2010· 5 cited
3′-[4-Aryl-(1,2,3-triazol-1-yl)]-3′-deoxythymidine Analogues as Potent and Selective Inhibitors of Human Mitochondrial Thymidine Kinase
Journal of Medicinal Chemistry·2010· 36 citedOpen Access
Two novel mutations in thymidine kinase-2 cause early onset fatal encephalomyopathy and severe mtDNA depletion
Neuromuscular Disorders·2010· 50 cited
Retained Sensitivity to Cytotoxic Pyrimidine Nucleoside Analogs in Thymidine Kinase 2 Deficient Human Fibroblasts
Nucleosides Nucleotides & Nucleic Acids·2009· 1 citedOpen Access
Evidence of an intact N-terminal translocation sequence of human mitochondrial adenylate kinase 4
The International Journal of Biochemistry & Cell Biology·2009· 33 cited
Identification of two active functional domains of human adenylate kinase 5
FEBS Letters·2009· 21 cited
Human Mitochondrial Thymidine Kinase Is Selectively Inhibited by 3′-Thiourea Derivatives of β-Thymidine: Identification of Residues Crucial for Both Inhibition and Catalytic Activity
Molecular Pharmacology·2009· 10 cited
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice
Human Molecular Genetics·2008· 96 citedOpen Access
Substrate specificity of feline and canine herpesvirus thymidine kinase
Antiviral Research·2008· 11 cited
Design, Synthesis and Anti Flaviviridae Activity of N6-, 5',3'-O- and 5',2'-O-Substituted Adenine Nucleoside Analogs
Chemical and Pharmaceutical Bulletin·2008· 21 citedOpen Access
Mitochondrial Expression of the Drosophila melanogaster Multisubstrate Deoxyribonucleoside Kinase
Molecular Pharmacology·2007· 4 cited
Novel selective human mitochondrial kinase inhibitors: Design, synthesis and enzymatic activity
Bioorganic & Medicinal Chemistry·2007· 9 citedOpen Access
Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design
BMC Structural Biology·2006· 38 citedOpen Access
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Frequent Co-authors

Anna Karlsson(26), Magnus Johansson(13), Stefano Manfredini(11), Silvia Vertuani(9), Angela Angusti(8), Jan Balzarini(7), Elisa Durini(6), Christakis Panayiotou(5), Mia Bjerke(5), Jan Balzarini(5), Marjan Amiri(3), Ana Negri(3), Federico Gago(3), Serge Van Calenbergh(3), Sabrina Pricl(3), Marco Ferrone(3), Erik De Clercq(3), Jan Balzarini(3), Björn Rozell(2), Nicole Lesko(2)