Jan Balzarini

Rega Institute for Medical Research — Belgium

Medicine · Health Sciences

59h-index13.9kcitations946works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(261), Synthesis and Characterization of Heterocyclic Compounds(157), Biochemical and Molecular Research(145), Synthesis and biological activity(121), HIV Research and Treatment(95)

Publications946 total

Benzothiazole Derivatives as Multifunctional Antioxidant Agents for Skin Damage: Structure–Activity Relationship of a Scaffold Bearing a Five-Membered Ring System
Antioxidants·2022· 37 citedOpen Access
Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1
Princeton University Press eBooks·2021· 1 cited
Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3′,4′,5′-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-c]pyridine Scaffold
Molecules·2020· 15 citedOpen Access
Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization
Bioorganic Chemistry·2020· 19 citedOpen Access
Synthesis of Heterocyclic Triterpene Derivatives with Biological Activities <i>via</i> Click Reaction
Current Organic Chemistry·2019· 3 citedOpen Access
Direct arylation of C<sub>60</sub>Cl<sub>6</sub> and C<sub>70</sub>Cl<sub>8</sub> with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity
Chemical Communications·2019· 35 citedOpen Access
Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells
Medicinal Chemistry·2018· 6 cited
Design, synthesis, <i>in vitro</i> antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach
Journal of Enzyme Inhibition and Medicinal Chemistry·2018· 22 citedOpen Access
2-Alkoxycarbonyl-3-arylamino-5-substituted thiophenes as a novel class of antimicrotubule agents: Design, synthesis, cell growth and tubulin polymerization inhibition
European Journal of Medicinal Chemistry·2017· 20 citedOpen Access
Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases
Trends in Parasitology·2017Open Access
A Multitarget Approach toward the Development of 8‐Substituted Purines for Photoprotection and Prevention of UV‐Related Damage
ChemMedChem·2017· 4 citedOpen Access
6-Benzylidene-2-[4-(pyridin-3-ylcarboxy)benzylidene]cyclohexanones: A novel cluster of tumour-selective cytotoxins
Bioorganic & Medicinal Chemistry Letters·2017· 3 cited
Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products
Organic & Biomolecular Chemistry·2017· 19 citedOpen Access
Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products
Organic & Biomolecular Chemistry·2017· 1 citedOpen Access
High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300
Scientific Reports·2016· 36 citedOpen Access
Synthesis and biological evaluation of novel mononuclear Ru(II) compounds as potential antiviral and cytotoxic agents
Lirias (KU Leuven)·2016Open Access
Correction to Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis—Binding of Foscarnet
ACS Chemical Biology·2016
Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models
PLoS Pathogens·2016· 16 citedOpen Access
Niacin esters of chalcones with tumor-selective properties
Journal of Enzyme Inhibition and Medicinal Chemistry·2016· 1 citedOpen Access
Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones
Molecules·2016· 41 citedOpen Access
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Frequent Co-authors

Erik De Clercq(30), Romeo Romagnoli(6), Pier Giovanni Baraldi(6), Lieve Naesens(5), Robert Snoeck(5), Graciela Andreï(5), Balasubramanian Narasimhan(4), María Dora Carriòn(4), M Cara(4), Mojgan Aghazadeh Tabrizi(4), Manlio Tolomeo(4), Stefania Grimaudo(4), Andrea Brancale(4), Ernest Hamel(4), Piet Herdewijn(4), Christophe Pannecouque(4), Carlo Federico Perno(3), Anna Karlsson(3), Vikramjeet Judge(3), Rakesh Narang(3)