Ernest Hamel

National Institutes of Health — United States

Chemistry · Physical Sciences

86h-index29.1kcitations658works2.22yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Synthesis and biological activity(276), Click Chemistry and Applications(98), Cancer Treatment and Pharmacology(98), Synthesis and Biological Evaluation(88), Microtubule and mitosis dynamics(82)

Publications658 total

Discovery of multitargeting single agents as a novel route to the potential treatment of neurodegenerative diseases
Bioorganic & Medicinal Chemistry Letters·2026Open Access
Ferroptosis Induction by a New Pyrrole Derivative in Triple Negative Breast Cancer and Colorectal Cancer
Journal of Medicinal Chemistry·2025· 1 cited
Benzosuberene and Tetracyclic Analogues as Colchicine Site Inhibitors of Tubulin Polymerization
ACS Medicinal Chemistry Letters·2025· 1 cited
Microwave-assisted synthesis of tubulin assembly inhibitors as anticancer agents by aryl ring reversal and conjunctive approach
RSC Medicinal Chemistry·2025· 1 citedOpen Access
Targeting tumor-associated hypoxia with bioreductively activatable prodrug conjugates derived from dihydronaphthalene, benzosuberene, and indole-based inhibitors of tubulin polymerization
RSC Medicinal Chemistry·2025· 1 citedOpen Access
Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents
Bioorganic & Medicinal Chemistry·2024· 3 citedOpen Access
Design, Synthesis and Biological Evaluation of 2-Phenyl Indole Analogues of OXi8006 as Colchicine Site Inhibitors of Tubulin Polymerization and Vascular Disrupting Agents
Bioorganic & Medicinal Chemistry·2024· 4 citedOpen Access
Drug-linker constructs bearing unique dual-mechanism tubulin binding payloads tethered through cleavable and non-cleavable linkers
Tetrahedron·2024· 1 citedOpen Access
Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule Agents
International Journal of Molecular Sciences·2024· 4 citedOpen Access
Combination treatment effect of an immunotherapeutic agent with microtubule inhibitors.
Journal of Clinical Oncology·2024
Copper(II) Complexes with Isomeric Morpholine-Substituted 2-Formylpyridine Thiosemicarbazone Hybrids as Potential Anticancer Drugs Inhibiting Both Ribonucleotide Reductase and Tubulin Polymerization: The Morpholine Position Matters
Journal of Medicinal Chemistry·2024· 13 citedOpen Access
Are the metal identity and stoichiometry of metal complexes important for colchicine site binding and inhibition of tubulin polymerization?
Dalton Transactions·2024Open Access
Synthesis and Structure-Activity Relationship of Boronic Acid Bioisosteres of Combretastatin A-4 as Anticancer Agents
SSRN Electronic Journal·2024Open Access
4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1<i>H</i>-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt/β-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells
Journal of Medicinal Chemistry·2023· 13 citedOpen Access
Synthesis and biological evaluation of structurally diverse 6-aryl-3-aroyl-indole analogues as inhibitors of tubulin polymerization
European Journal of Medicinal Chemistry·2023· 14 citedOpen Access
CCDC 2261960: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
CCDC 2261963: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
CCDC 2261962: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
CCDC 2261961: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
CCDC 2261959: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
page 1 of 33Next →

Frequent Co-authors

George R. Pettit(8), Chii M. Lin(6), Billy W. Day(5), Andrea Brancale(5), Pascal Verdier‐Pinard(5), Sheo B. Singh(4), Robin K. Pettit(4), Michael Edler(4), M. Katherine Jung(4), C. Michael Lin(3), Richard Kowalski(3), Paraskevi Giannakakou(3), Kenneth F. Bastow(3), Kuo‐Hsiung Lee(3), Dionisios Vourloumis(3), William H. Gerwick(3), Gabriella Martino(3), Giuseppe La Regina(3), Antonio Coluccia(3), Marino Artico(3)