David Lyden

Cornell University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

75h-index52.9kcitations309works15.82yr avg
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Research Topics

Extracellular vesicles in disease(90), Cancer Cells and Metastasis(50), MicroRNA in disease regulation(39), Immune cells in cancer(39), Angiogenesis and VEGF in Cancer(31)

Publications306 total

FGF13 is not secreted from mouse neurons
JCI Insight·2025Open Access
FGF13 is not secreted from neurons
2025
HTRS2025.O6B.6 SARS-CoV-2 ORF3a Drives Pulmonary Epithelial Extracellular Vesicle Production During COVID-19
Research and Practice in Thrombosis and Haemostasis·2025Open Access
Interrogation of exosome-mediated intercellular signaling and pre-metastatic niche establishment for diagnostic biomarkers in patients with ovarian cancer
Gynecologic Oncology·2025
Abstract P1-04-17: Exosomes as drivers and biomarkers of TAM recruitment and immune evasion in inflammatory breast cancer
Clinical Cancer Research·2025
Abstract 585: Utilizing CAR T cell-derived exosomes for radiotheranostic applications
Cancer Research·2025· 1 cited
Soluble CD13 is a potential mediator of neutrophil-induced thrombogenic inflammation in SARS-CoV-2 infection
JCI Insight·2025· 4 citedOpen Access
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2
Cell·2025· 35 citedOpen Access
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression
Nature Cancer·2024· 18 citedOpen Access
Abstract PR014: DNA associated with EVs is uniquely chromatinized and prevents metastasis by enhancing anti-tumor immunity
Cancer Research·2024· 1 cited
MAP kinase kinase 1 (MEK1) within extracellular vesicles inhibits tumour growth by promoting anti‐tumour immunity
Journal of Extracellular Vesicles·2024· 2 citedOpen Access
High-quality Scanning Electron Microscopy Incorporated with a Freeze-drying and Gaseous Nitrogen-based Approach for Cell-extracellular Vesicle Interactions
Microscopy and Microanalysis·2024
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Nature Medicine·2024· 41 citedOpen Access
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Nature Communications·2024· 50 citedOpen Access
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Nature·2024· 90 citedOpen Access
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
Nature Communications·2024· 31 citedOpen Access
Molecular and physiological changes in the SpaceX Inspiration4 civilian crew
Nature·2024· 50 citedOpen Access
Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load
Cell Reports·2024· 19 citedOpen Access
Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential
Research Square (Research Square)·2024· 2 citedOpen Access
Abstract 1038: Identification of diagnostic biomarkers for colon adenocarcinoma by analyzing proteins in human-derived extracellular vesicles and particles
Cancer Research·2024· 3 cited
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Frequent Co-authors

Shahin Rafii(20), Héctor Peinado(12), Jacqueline Bromberg(12), Irina Matei(11), Ayuko Hoshino(8), Haiying Zhang(8), Rosandra N. Kaplan(8), Beate Heissig(8), Koichi Hattori(7), Bruno Costa‐Silva(6), Daniel J. Hicklin(6), Sérgio Dias(6), Neil R. Hackett(6), Ronald G. Crystal(6), Linda Bojmar(5), Cyrus M. Ghajar(5), Zhenping Zhu(5), Sergey V. Shmelkov(5), Robert Benezra(5), Gonçalo Rodrigues(4)