Neil R. Hackett

Cornell University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

64h-index17.5kcitations226works4.32yr avg
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Research Topics

Virus-based gene therapy research(64), Lysosomal Storage Disorders Research(26), Neonatal Respiratory Health Research(23), Angiogenesis and VEGF in Cancer(20), RNA Interference and Gene Delivery(15)

Publications226 total

Prime Editing of Alzheimer’s Disease High-Risk APOE4 Allele by Brain-Directed Adeno-Associated Virus Vectors
Human Gene Therapy·2025· 1 cited
Four decades of adenovirus gene transfer vectors: History and current use
Molecular Therapy·2025· 4 cited
Twenty-Year Survival Analysis of Adeno-Associated Virus Vector Serotype 2-Mediated Gene Therapy to the Central Nervous System for CLN2 Disease
Human Gene Therapy·2025· 3 citedOpen Access
CNS Gene Therapy for APOE4 Homozygote-Associated Alzheimer’s Disease
Translational Neuroscience·2025Open Access
Vectorized Human Antibody-Mediated Anti-Eosinophil Gene Therapy
Human Gene Therapy·2024Open Access
AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer’s disease mice
Molecular Therapy·2024· 13 citedOpen Access
Pre-clinical development of AP4B1 gene replacement therapy for hereditary spastic paraplegia type 47
EMBO Molecular Medicine·2024· 11 citedOpen Access
Suppression of CNS APOE4 Expression by miRNAs Delivered by the S2 AAVrh.10 Capsid-Modified AAV Vector
Human Gene Therapy·2024· 2 cited
Combination HSCT and intravenous AAV-mediated gene therapy in a canine model proves pivotal for translation of Krabbe disease therapy
Molecular Therapy·2023· 10 citedOpen Access
Predicted deleterious variants in the human genome relevant to gene therapy with adeno-associated virus vectors
Molecular Therapy — Methods & Clinical Development·2023· 3 citedOpen Access
Gene Therapy-mediated Angiogenesis of Transplanted Fat
Plastic & Reconstructive Surgery Global Open·2023Open Access
Data from Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking, COPD, and Lung Cancer
2023Open Access
Supplementary Methods and Materials, Supplementary Tables 1-2, Supplemental Figure Legends, Supplementary Figure 1 from Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking, COPD, and Lung Cancer
2023Open Access
Data from Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking, COPD, and Lung Cancer
2023Open Access
Supplementary Methods and Materials, Supplementary Tables 1-2, Supplemental Figure Legends, Supplementary Figure 1 from Modulation of Cystatin A Expression in Human Airway Epithelium Related to Genotype, Smoking, COPD, and Lung Cancer
2023Open Access
Slowing late infantile Batten disease by direct brain parenchymal administration of a rh.10 adeno-associated virus expressing <i>CLN2</i>
Science Translational Medicine·2020· 67 citedOpen Access
Correction: Type 2 Diabetes Risk Allele Loci in the Qatari Population
PLoS ONE·2016· 5 citedOpen Access
Type 2 Diabetes Risk Allele Loci in the Qatari Population
PLoS ONE·2016· 37 citedOpen Access
(purple membrane/proton pump/oligonucleotide purification/site-sp4
2016
Genetic modification of neurons to express bevacizumab for local anti-angiogenesis treatment of glioblastoma
Cancer Gene Therapy·2014· 27 citedOpen Access
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Frequent Co-authors

Ronald G. Crystal(40), Shahin Rafii(9), Barbara Ferris(8), Dolan Sondhi(8), Ben‐Gary Harvey(8), Beate Heissig(7), Todd K. Rosengart(7), Stefan Worgall(7), David Lyden(6), Malcolm A.S. Moore(6), Imre Kovesdi(6), Philip L. Leopold(6), Jacqueline Salit(6), Koichi Hattori(5), Sérgio Dias(5), Daniel J. Hicklin(5), O. Wayne Isom(5), Timothy P. O’Connor(5), Larry Witte(4), Zhenping Zhu(4)