Christopher M. Koth

Denali Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

33h-index4.8kcitations74works33.22yr avg
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Research Topics

RNA and protein synthesis mechanisms(16), Bacterial Genetics and Biotechnology(12), Ion channel regulation and function(12), Drug Transport and Resistance Mechanisms(7), Nicotinic Acetylcholine Receptors Study(7)

Publications74 total

Disulfide-constrained Fabs overcome target size limitation for high-resolution single particle cryoEM
Nature Communications·2025· 1 citedOpen Access
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
Cell Reports·2025· 6 citedOpen Access
Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules
2025· 2 citedOpen Access
Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes
Cell·2024· 63 citedOpen Access
Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier
Science Translational Medicine·2024· 94 cited
Development of an 18F-labeled anti-human CD8 VHH for same-day immunoPET imaging
European Journal of Nuclear Medicine and Molecular Imaging·2022· 21 cited
Discovery of Inhibitors of the Lipopolysaccharide Transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-Negative Activity
Journal of Medicinal Chemistry·2022· 28 cited
Taking away PAIN: enabling new structures of the Nav1.7 sodium channel by cryo-EM
Acta Crystallographica Section A Foundations and Advances·2021Open Access
Structural and functional diversity calls for a new classification of ABC transporters
FEBS Letters·2020· 273 citedOpen Access
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
Science·2020· 184 citedOpen Access
Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7
Cell chemical biology·2019· 22 citedOpen Access
Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD
eLife·2019· 34 citedOpen Access
Author response: Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD
2019Open Access
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
PubMed·2019· 141 cited
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin
Cell·2019· 71 citedOpen Access
Structural Basis of Nav1.7 Inhibition by the Tarantula Toxin Protoxin-II
Biophysical Journal·2019· 2 citedOpen Access
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin
Cell·2019· 181 citedOpen Access
A Flexible and Scalable High-Throughput Platform for Recombinant Membrane Protein Production
Methods in molecular biology·2019· 3 cited
Structural basis of selective Nav1.7 inhibition by a gating-modifier spider toxin
Cell·2019· 1 cited
Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA
Antimicrobial Agents and Chemotherapy·2018· 73 citedOpen Access
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Frequent Co-authors

Jian Payandeh(16), A.M. Edwards(12), Susmith Mukund(7), Christine Tam(7), Alberto Estevez(7), Yvonne Franke(7), David H. Hackos(7), C.H. Arrowsmith(7), Christine Kugel(6), Tianbo Li(6), Hoangdung Ho(5), Christopher P. Arthur(5), Claudio Ciferri(5), Alexis Rohou(5), Foteini Tzakoniati(5), Mary Kate Alexander(5), Mireille Nishiyama(5), Ángel Raya(4), Dirk Büscher(4), Yasuhiko Kawakami(4)