David R. Adams

University of Kentucky — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index6.4kcitations170works32.72yr avg
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Research Topics

Phosphodiesterase function and regulation(27), Receptor Mechanisms and Signaling(24), Chemical synthesis and alkaloids(18), Cholinesterase and Neurodegenerative Diseases(16), Synthesis and Biological Evaluation(15)

Publications170 total

Morrey-to-Campanato regularities for divergence-like equations
Mathematische Annalen·2025
Elliptic‐to‐parabolic Morrey spaces–potentials–capacities with applications to certain evolution PDE
Journal of the London Mathematical Society·2025· 4 cited
De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome
Nature·2024· 94 citedOpen Access
Dependence of IL-7R-Mediated Signaling on Sphingosine Kinase Activity in Acute Lymphoblastic Leukemia, but Not Healthy Lymphoid Cells, Is an Exploitable Therapeutic Vulnerability
Blood·2023Open Access
Antibiotic Prophylaxis in Oral and Maxillofacial Surgery: Recent Trends in Therapeutic Applications
2023Open Access
Large-Scale Pilot Test Leads to Successful Coating Specification and Application in a Major Wastewater Rehabilitation Facility
2023
Pharmacological Activation of Long-Form PDE4 Enzymes Suppresses Disease Progression in Pkd1RC/RC and Pkd1 Knockout (iKspCrePkd-1lox,lox) Mouse Models of ADPKD
Journal of the American Society of Nephrology·2021
Dihydroceramide Desaturase Functions as an Inducer and Rectifier of Apoptosis: Effect of Retinol Derivatives, Antioxidants and Phenolic Compounds
Cell Biochemistry and Biophysics·2021· 9 citedOpen Access
A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells
Journal of Biological Chemistry·2021· 3 citedOpen Access
Validation of highly selective sphingosine kinase 2 inhibitors SLM6031434 and HWG-35D as effective anti-fibrotic treatment options in a mouse model of tubulointerstitial fibrosis
Cellular Signalling·2020· 18 cited
A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes
International Journal of Molecular Sciences·2020· 17 citedOpen Access
Drugs for the Skinternist
Elsevier eBooks·2020· 1 cited
Structure-function analysis of lipid substrates and inhibitors of sphingosine kinases
Cellular Signalling·2020· 14 cited
Small-Molecule Allosteric Activators of Long-Form PDE4 Enzymes Suppress Cystogenesis in Models of ADPKD
Journal of the American Society of Nephrology·2020· 1 cited
Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
Proceedings of the National Academy of Sciences·2019· 77 citedOpen Access
2. "The Drive to Be at Home Everywhere"
Cornell University Press eBooks·2019
Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2
Journal of Medicinal Chemistry·2019· 35 citedOpen Access
The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts
Oncotarget·2018· 32 citedOpen Access
Sphingosine Kinases as Druggable Targets
Handbook of experimental pharmacology·2018· 14 cited
Design and synthesis of a potent, highly selective, orally bioavailable, retinoic acid receptor alpha agonist
Bioorganic & Medicinal Chemistry·2017· 9 citedOpen Access
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Frequent Co-authors

Miles D. Houslay(17), George S. Baillie(15), Zhong‐Tao Jiang(10), Enno Klußmann(8), Nigel J. Pyne(6), Robert W. Allcock(6), J. Grant Burgess(5), Kenneth G. Boyd(5), Susan Pyne(5), Graeme B. Bolger(5), Allan J. Dunlop(5), Graeme Milligan(5), Patrick A. Kiely(4), Tomáš Hudlický(4), Yasushi Kohno(4), Dorit Ron(3), Karen Benwell(3), Rosemary O’Connor(3), Christian Frank(3), Thomas M. Houslay(3)