Karen Benwell

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.2kcitations34works0.02yr avg
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Research Topics

Adenosine and Purinergic Signaling(7), Neurotransmitter Receptor Influence on Behavior(6), Pharmacological Receptor Mechanisms and Effects(6), Receptor Mechanisms and Signaling(5), Synthesis and Biological Evaluation(5)

Publications34 total

Targeting DYRK1A/B kinases to modulate p21‐cyclin D1‐p27 signalling and induce anti‐tumour activity in a model of human glioblastoma
Journal of Cellular and Molecular Medicine·2021· 25 citedOpen Access
Fragment-Derived Selective Inhibitors of Dual-Specificity Kinases DYRK1A and DYRK1B
Journal of Medicinal Chemistry·2021· 35 citedOpen Access
Structure-Guided Discovery of Potent and Selective DYRK1A Inhibitors
Journal of Medicinal Chemistry·2021· 33 citedOpen Access
Abstract B163: Identification and preclinical characterisation of VER-250840, a potent, selective Chk1 inhibitor with in vivo oral single-agent antitumor activity
Molecular Cancer Therapeutics·2018
Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity
Bioorganic & Medicinal Chemistry Letters·2011· 10 citedOpen Access
CCDC 731592: Experimental Crystal Structure Determination
The Cambridge Structural Database·2010Open Access
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor
Bioorganic & Medicinal Chemistry Letters·2009· 10 citedOpen Access
Discovery and functional evaluation of diverse novel human CB1 receptor ligands
Bioorganic & Medicinal Chemistry Letters·2009· 20 citedOpen Access
Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
Bioorganic & Medicinal Chemistry Letters·2009· 30 citedOpen Access
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives
Bioorganic & Medicinal Chemistry Letters·2008· 48 citedOpen Access
The cannabinoid CB1 receptor inverse agonist, rimonabant, modifies body weight and adiponectin function in diet-induced obese rats as a consequence of reduced food intake
Pharmacology Biochemistry and Behavior·2006· 83 cited
Pyrrolo(iso)quinoline derivatives as 5-HT2C receptor agonists
Bioorganic & Medicinal Chemistry Letters·2005· 26 citedOpen Access
Mefloquine as a starting point for the discovery of selective adenosine A(2A) receptor antagonists
Abstracts of papers - American Chemical Society·2005
O14 THE CANNABINOID CB1 RECEPTOR INVERSE AGONIST, RIMONABANT, MODIFIES BODY WEIGHT AND ADIPONECTIN mRNA BY MODULATING FOOD INTAKE
Behavioural Pharmacology·2005
Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors
Naunyn-Schmiedeberg s Archives of Pharmacology·2004· 237 citedOpen Access
Indoline derivatives as 5-HT 2C receptor agonists
Bioorganic & Medicinal Chemistry Letters·2004· 44 citedOpen Access
Novel purine derivatives as selective adenosine A(2A) receptor antagonists for the treatment of Parkinson's disease.
Abstracts of papers - American Chemical Society·2004
Evaluation of analogues of (-)-mefloquine as adenosine A(2A) receptor antagonists.
Abstracts of papers - American Chemical Society·2004
Synthesis and evaluation of novel pyrazolo[3,4-d] pyrimidine derivatives as selective adenosine A(2A) receptor antagonists.
Abstracts of papers - American Chemical Society·2004
Synthesis and SAR of novel thieno[3,2-d]pyrimidine derivatives as selective antagonists of the adenosine A(2A) receptor.
Abstracts of papers - American Chemical Society·2004
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Frequent Co-authors

G.A. Kennett(16), Colin T. Dourish(16), Ian A. Cliffe(15), Aditya Misra(11), Robert M. Pratt(10), Anil Kumar Misra(8), Mike Bickerdike(8), S P Vickers(8), Scott Μ. Weiss(8), Suneel Gaur(8), Howard L. Mansell(8), T Knight(8), C Malcolm(7), R. J. Gillespie(7), Joanne Lerpiniere(7), Claire Dawson(7), Richard H. Porter(6), Dean F. Revell(6), Rebecca Upton(6), Paul R. Giles(6)