Mateusz Legut

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index3.4kcitations46works0.02yr avg
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Research Topics

CRISPR and Genetic Engineering(17), CAR-T cell therapy research(17), Immune Cell Function and Interaction(15), T-cell and B-cell Immunology(9), Immunotherapy and Immune Responses(9)

Publications44 total

A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling
2026Open Access
Paired CRISPR screens to map gene regulation in <i>cis</i> and <i>trans</i>
2024Open Access
Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
Cell·2023· 115 citedOpen Access
Multiomics-guided cellular immunotherapies
Nature reviews. Cancer·2023· 5 cited
Endovascular treatment of infrarenal aortic aneurysm using the ANKURA stent graft – one-center case series
Advances in Interventional Cardiology·2023· 1 citedOpen Access
Preclinical Development of Lymphotoxin Beta Receptor-Overexpressing CAR T Cells Demonstrates Potentiation of CAR T Cell Antitumor Activity
Blood·2022
Expanding the Scope of Bacterial CRISPR Activation with PAM-Flexible dCas9 Variants
ACS Synthetic Biology·2022· 19 citedOpen Access
Publisher Correction: Recurrent somatic mutations as predictors of immunotherapy response
Nature Communications·2022· 1 citedOpen Access
Expanding the scope of bacterial CRISPR activation with PAM-flexible dCas9 variants
2022· 1 citedOpen Access
Recurrent somatic mutations as predictors of immunotherapy response
Nature Communications·2022· 29 citedOpen Access
A genome-scale screen for synthetic drivers of T cell proliferation
Nature·2022· 173 citedOpen Access
Ligand Identification for Orphan MHC-Agnostic T-Cell Receptors by Whole Genome CRISPR–Cas9 Screening
Methods in molecular biology·2022
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells
Cell chemical biology·2021· 56 citedOpen Access
Chemically modified guide RNAs enhance CRISPR-Cas13 knockdown in human cells
2021· 12 citedOpen Access
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
Cell·2020· 628 citedOpen Access
Massively parallel Cas13 screens reveal principles for guide RNA design
Nature Biotechnology·2020· 426 citedOpen Access
Author Correction: Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
Nature Immunology·2020· 4 citedOpen Access
High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
Cell Reports·2020· 70 citedOpen Access
High-throughput screens of PAM-flexible Cas9 variants for gene knock-out and transcriptional modulation
2020· 14 citedOpen Access
Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1
Nature Immunology·2020· 252 citedOpen Access
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Frequent Co-authors

Andrew K. Sewell(18), Neville E. Sanjana(17), Garry Dolton(10), Zharko Daniloski(8), Hans‐Hermann Wessels(8), David K. Cole(7), Anna Fuller(7), Meriem Attaf(6), Barbara Szomolay(6), Marco Donia(6), Inge Marie Svane(6), Cristina Rius(5), Xinhe Xue(5), Eleni P. Mimitou(4), Peter Smibert(4), Alejandro Méndez‐Mancilla(4), Michael D. Crowther(4), Alan L. Parker(4), Zoran Gajic(4), P.J. Rizkallah(4)