Hans‐Hermann Wessels

New York Genome Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index3.1kcitations50works12.22yr avg
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Research Topics

RNA Research and Splicing(23), CRISPR and Genetic Engineering(20), RNA and protein synthesis mechanisms(12), RNA modifications and cancer(12), Single-cell and spatial transcriptomics(11)

Publications50 total

Retraction notice to: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
Cell·2025Open Access
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
Nature Communications·2025· 6 citedOpen Access
Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens
Nature Cell Biology·2025· 18 cited
Precise RNA targeting with CRISPR–Cas13d
Nature Biotechnology·2025· 10 cited
Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens
Zenodo (CERN European Organization for Nuclear Research)·2024Open Access
Paired CRISPR screens to map gene regulation in <i>cis</i> and <i>trans</i>
2024Open Access
Active learning for efficient discovery of optimal gene combinations in the combinatorial perturbation space
arXiv (Cornell University)·2024Open Access
RETRACTED: Transcriptome-scale RNA-targeting CRISPR screens reveal essential lncRNAs in human cells
Cell·2024· 55 citedOpen Access
Multiplexed single-cell characterization of alternative polyadenylation regulators (HEK293FT & K562 Perturb-seq data)
Zenodo (CERN European Organization for Nuclear Research)·2024· 1 citedOpen Access
Multiplexed single-cell characterization of alternative polyadenylation regulators
Cell·2024· 39 citedOpen Access
Low copy CRISPR-Cas13d mitigates collateral RNA cleavage
2024· 7 citedOpen Access
Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens
2024· 20 citedOpen Access
Systematic reconstruction of molecular pathway signatures using scalable single-cell perturbation screens
Zenodo (CERN European Organization for Nuclear Research)·2024· 1 citedOpen Access
Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
2023· 6 citedOpen Access
Prediction of on-target and off-target activity of CRISPR–Cas13d guide RNAs using deep learning
Nature Biotechnology·2023· 105 cited
CPA-Perturb-seq: Multiplexed single-cell characterization of alternative polyadenylation regulators
2023· 8 citedOpen Access
CPA-Perturb-seq: Multiplexed single-cell characterization of alternative polyadenylation regulators (PBMC data)
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
CPA-Perturb-seq: Multiplexed single-cell characterization of alternative polyadenylation regulators (Perturb-seq data)
2023Open Access
CPA-Perturb-seq: Multiplexed single-cell characterization of alternative polyadenylation regulators (PBMC data)
2023Open Access
Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq
Nature Methods·2022· 75 citedOpen Access
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Frequent Co-authors

Neville E. Sanjana(22), Alejandro Méndez‐Mancilla(15), Rahul Satija(14), Uwe Ohler(10), Carol Dalgarno(10), Isabella Mascio(10), Yuhan Hao(9), Mateusz Legut(8), Efthymia Papalexi(8), Peter Smibert(7), Madeline H. Kowalski(6), Johannes Linder(6), Saket Choudhary(6), Austin Hartman(6), Anshul Kundaje(6), Zharko Daniloski(5), Eleni P. Mimitou(5), Xinyi Guo(5), Sydney K. Hart(5), Lu Lu(4)