Torsten Schaller

Immunology and Microbiology · Life Sciences

27h-index4.2kcitations54works9.52yr avg
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Research Topics

HIV Research and Treatment(27), interferon and immune responses(12), Herpesvirus Infections and Treatments(10), Cytomegalovirus and herpesvirus research(10), Immune Cell Function and Interaction(7)

Publications54 total

Safety and efficacy of monoclonal antibody therapy in patients with chronic herpes simplex virus-2 genital infections: MATCH-2, a randomized double-blinded, parallel-group phase 2 multi-center trial
Pharmacological Research·2025· 2 citedOpen Access
Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus
Journal of Biomedical Science·2024· 17 citedOpen Access
Safety and Efficacy of Single HDIT101 Infusion Versus Episodic Valacyclovir Standard-of-Care in Patients with Chronic Recurrent Anogenital Herpes Simplex Virus 2 (HSV-2) Infection: A Multicentre, Parallel-Group Design, Randomised, Double-Blind, Double-Dummy Phase 2 Trial
SSRN Electronic Journal·2023Open Access
Targeting SAMHD1 with hydroxyurea in first‐line cytarabine‐based therapy of newly diagnosed acute myeloid leukaemia: Results from the HEAT‐AML trial
Journal of Internal Medicine·2022· 17 citedOpen Access
First‐in‐human, randomized, double‐blind, placebo‐controlled, dose escalation trial of the anti‐herpes simplex virus monoclonal antibody <scp>HDIT101</scp> in healthy volunteers
Clinical and Translational Science·2022· 13 citedOpen Access
P543: TARGETING SAMHD1 WITH HYDROXYUREA IN FIRST-LINE CYTARABINE-BASED THERAPY OF NEWLY DIAGNOSED ACUTE MYELOID LEUKAEMIA: RESULTS FROM THE HEAT-AML TRIAL
HemaSphere·2022· 1 citedOpen Access
Development and Validation of an LC–MS-Based Quantification Assay for New Therapeutic Antibodies: Application to a Novel Therapy against Herpes Simplex Virus
ACS Omega·2020· 15 citedOpen Access
Development of a chemical probe against NUDT15
Nature Chemical Biology·2020· 25 citedOpen Access
Ribonucleotide reductase inhibitors suppress <scp>SAMHD</scp> 1 ara‐ <scp>CTP</scp> ase activity enhancing cytarabine efficacy
EMBO Molecular Medicine·2020· 57 citedOpen Access
Evidence for SAMHD1 Tumor Suppressor Functions in Acute Myeloid Leukemia
Acta Haematologica·2019· 3 citedOpen Access
The ability of SAMHD1 to block HIV-1 but not SIV requires expression of MxB
Virology·2019· 18 citedOpen Access
Human SAMHD1 restricts the xenotransplantation relevant porcine endogenous retrovirus (PERV) in non-dividing cells
Journal of General Virology·2019· 6 cited
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens
Blood Cancer Journal·2018· 42 citedOpen Access
Herpevizumab, a potent humanized antibody to treat anogenital herpes simplex virus (HSV-1/2) infection – Summary of preclinical data and perspectives of an ongoing clinical trial
Geburtshilfe und Frauenheilkunde·2018· 1 cited
Human MxB Protein Is a Pan-herpesvirus Restriction Factor
Journal of Virology·2018· 110 citedOpen Access
Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection
Journal of Virology·2017· 24 citedOpen Access
With me or against me: Tumor suppressor and drug resistance activities of SAMHD1
Experimental Hematology·2017· 49 cited
SAMHD1 protects cancer cells from various nucleoside-based antimetabolites
Cell Cycle·2017· 73 citedOpen Access
SAMHD1 is a barrier to antimetabolite-based cancer therapies
Molecular & Cellular Oncology·2017· 18 citedOpen Access
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
Nature Medicine·2017· 141 cited
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Frequent Co-authors

Greg J. Towers(14), Nikolas Herold(12), Michael H. Malim(9), Juliane Kutzner(9), Caroline Goujon(7), Sean G. Rudd(7), Jan‐Inge Henter(7), Leo C. James(6), Stéphane Hué(5), Amanda J. Price(5), Adam J. Fletcher(5), Thomas Helleday(5), Jürgen Krauß(5), Nicole Appel(4), Ralf Bartenschlager(4), Kumar Sanjiv(4), Ida Hed Myrberg(4), Cynthia B. J. Paulin(4), Lorenzo Bulli(4), Georgios Z. Rassidakis(4)