Marilyn C. Darkes

Medicine · Health Sciences

15h-index1.2kcitations22works0.02yr avg
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Research Topics

Nitric Oxide and Endothelin Effects(5), HIV Research and Treatment(4), Chemokine receptors and signaling(4), Crystallization and Solubility Studies(4), X-ray Diffraction in Crystallography(4)

Publications22 total

The molecular pharmacology of AMD11070: An orally bioavailable CXCR4 HIV entry inhibitor
Biochemical Pharmacology·2011· 52 cited
Prospective CCR5 Small Molecule Antagonist Compound Design Using a Combined Mutagenesis/Modeling Approach
Journal of the American Chemical Society·2011· 16 cited
HIV-1 entry inhibition by small-molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high-throughput assay
Virology·2011· 26 cited
Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Bioorganic & Medicinal Chemistry Letters·2011· 7 cited
Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4
Biochemical Pharmacology·2009· 55 cited
Characterization of the molecular pharmacology of AMD3100: A specific antagonist of the G-protein coupled chemokine receptor, CXCR4
Biochemical Pharmacology·2006· 216 cited
The Development of an Europium-GTP Assay to Quantitate Chemokine Antagonist Interactions for CXCR4 and CCR5
Assay and Drug Development Technologies·2005· 16 cited
Ru<sup>III</sup> Complexes of Edta and Dtpa Polyaminocarboxylate Analogues and Their Use as Nitric Oxide Scavengers
European Journal of Inorganic Chemistry·2005· 26 citedOpen Access
CCDC 251648: Experimental Crystal Structure Determination
The Cambridge Structural Database·2005Open Access
Ruthenium(III) Triazacyclononane Dithiocarbamate, Pyridinecarboxylate, or Aminocarboxylate Complexes as Scavengers of Nitric Oxide
Inorganic Chemistry·2003· 41 cited
Increased matrix metalloproteinase activity after canine cardiopulmonary bypass is suppressed by a nitric oxide scavenger
Journal of Thoracic and Cardiovascular Surgery·2003· 26 citedOpen Access
Ruthenium(III) Polyaminocarboxylate Complexes:  Efficient and Effective Nitric Oxide Scavengers
Inorganic Chemistry·2003· 55 cited
CCDC 207970: Experimental Crystal Structure Determination
The Cambridge Structural Database·2003Open Access
CCDC 207971: Experimental Crystal Structure Determination
The Cambridge Structural Database·2003Open Access
CCDC 207969: Experimental Crystal Structure Determination
The Cambridge Structural Database·2003Open Access
A Ruthenium (III) Polyaminocarboxylate Complex, A Novel Nitric Oxide Scavenger, Enhances Graft Survival and Decreases Nitrosylated Heme Protein in Models of Acute and Delayed Cardiac Transplant Rejection
Journal of Cardiovascular Pharmacology·2002· 32 cited
Mechanistic Studies on AMD6221: A Ruthenium-Based Nitric Oxide Scavenger
Biochemical and Biophysical Research Communications·2002· 35 cited
<i>In vivo</i> detection and imaging of phosphatidylserine expression during programmed cell death
Proceedings of the National Academy of Sciences·1998· 538 citedOpen Access
The synthesis and in vitro photodynamic activity of a series of novel ruthenium(II)-2,3-naphthalocyanines
Journal of Photochemistry and Photobiology B Biology·1997· 14 cited
Pharmacokinetics of Polyoxometalates after Multiple‐dose Administration in Rats
Pharmacy and Pharmacology Communications·1996· 4 cited
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Frequent Co-authors

Simon P. Fricker(18), Gary Bridger(12), Renato T. Skerlj(11), Beth R. Cameron(10), Jean Labrecque(7), Gloria Lau(7), Nathan Davies(6), Michael T. Wilson(6), Renée Mosi(5), Rebecca S.Y. Wong(4), David J. Rose(4), Zefferino Santucci(4), Dominique Schols(4), Gerald E. Bossard(4), Hooi Min Yee(4), Michael J. Abrams(3), Virginia Anastassov(3), Stefan R. Idzan(3), Kim L. Nelson(3), Markus Metz(3)