Jean Labrecque

Medical Council of Canada — Canada

Medicine · Health Sciences

16h-index1.5kcitations36works2.02yr avg
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Research Topics

Chemokine receptors and signaling(8), HIV Research and Treatment(6), Retinoids in leukemia and cellular processes(6), Heart Failure Treatment and Management(5), Immunotherapy and Immune Responses(5)

Publications36 total

A combined digital microfluidic test for assessing infection and immunity status for viral disease in saliva
Lab on a Chip·2025· 2 citedOpen Access
Machine Learning to Automate the Visual Interpretation of Chemical Agglutination Tests
2022 IEEE International Conference on Pervasive Computing and Communications Workshops and other Affiliated Events (PerCom Workshops)·2022· 2 cited
Specificity for a CCR5 Inhibitor Is Conferred by a Single Amino Acid Residue
Journal of Biological Chemistry·2015· 9 citedOpen Access
Discovery of a series of aryl-N-(3-(alkylamino)-5-(trifluoromethyl)phenyl)benzamides as TRPA1 antagonists
Bioorganic & Medicinal Chemistry Letters·2014· 13 citedOpen Access
Discovery of a 4-aryloxy-1H-pyrrolo[3,2-c]pyridine and a 1-aryloxyisoquinoline series of TRPA1 antagonists
Bioorganic & Medicinal Chemistry Letters·2014· 15 citedOpen Access
RARα-PLZF oncogene inhibits C/EBPα function in myeloid cells
Proceedings of the National Academy of Sciences·2013· 32 citedOpen Access
Novel Methodology to Identify TRPV1 Antagonists Independent of Capsaicin Activation
SLAS DISCOVERY·2012· 11 citedOpen Access
The orally bioavailable allosteric CXCR4 HIV-1 entry inhibitor AMD11070
Retrovirology·2012· 1 citedOpen Access
Discovery of P2X3 selective antagonists for the treatment of chronic pain
Bioorganic & Medicinal Chemistry Letters·2012· 30 citedOpen Access
The molecular pharmacology of AMD11070: An orally bioavailable CXCR4 HIV entry inhibitor
Biochemical Pharmacology·2011· 52 cited
Prospective CCR5 Small Molecule Antagonist Compound Design Using a Combined Mutagenesis/Modeling Approach
Journal of the American Chemical Society·2011· 16 cited
HIV-1 entry inhibition by small-molecule CCR5 antagonists: A combined molecular modeling and mutant study using a high-throughput assay
Virology·2011· 26 cited
Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication
Bioorganic & Medicinal Chemistry Letters·2011· 7 cited
Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4
Biochemical Pharmacology·2009· 55 cited
A Time-Resolved Fluorescent Lanthanide (Eu)-GTP Binding Assay for Chemokine Receptors as Targets in Drug Discovery
Methods in molecular biology·2009· 16 cited
Comparison of the Potential Multiple Binding Modes of Bicyclam, Monocylam, and Noncyclam Small-Molecule CXC Chemokine Receptor 4 Inhibitors
Molecular Pharmacology·2008· 126 cited
The RARa-PLZF Oncogenic Protein Inhibits C/EBPa Function in Myeloid Cells.
Blood·2007· 1 cited
Characterization of the molecular pharmacology of AMD3100: A specific antagonist of the G-protein coupled chemokine receptor, CXCR4
Biochemical Pharmacology·2006· 216 cited
The Development of an Europium-GTP Assay to Quantitate Chemokine Antagonist Interactions for CXCR4 and CCR5
Assay and Drug Development Technologies·2005· 16 cited
Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model
Blood·2005· 80 citedOpen Access
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Frequent Co-authors

Simon P. Fricker(12), Gloria Lau(8), Gary Bridger(8), Marilyn C. Darkes(7), Rebecca S.Y. Wong(7), Renée Mosi(5), Markus Metz(5), Renato T. Skerlj(5), Dominique Schols(5), Trang Hoang(4), André De Léan(4), Virginia Anastassov(3), Stefan R. Idzan(3), Kim L. Nelson(3), Zefferino Santucci(3), Dana Huskens(3), Serge Cazelais(3), Michael Kaler(3), Louis Painchaud(3), Eric Grazzini(2)