J. Richard Morphy

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.3kcitations50works0.02yr avg
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Research Topics

Chemical Synthesis and Analysis(18), Chemical Synthesis and Reactions(7), Protease and Inhibitor Mechanisms(6), Monoclonal and Polyclonal Antibodies Research(6), Radiopharmaceutical Chemistry and Applications(6)

Publications50 total

Hydrogen-Bonding Phase-Transfer Catalyst Enabled Asymmetric Fluorination
Synfacts·2018
Asymmetric nucleophilic fluorination under hydrogen bonding phase-transfer catalysis
Science·2018· 183 cited
CCDC 1812187: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
CCDC 1812188: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
The dual role of thiourea in the thiotrifluoromethylation of alkenes
Chemical Science·2016· 46 citedOpen Access
CCDC 1474241: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
CCDC 1474239: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
CCDC 1474240: Experimental Crystal Structure Determination
The Cambridge Structural Database·2016Open Access
Medicinal Chemistry Strategies to Prevent Compound Attrition
2015
ChEMBLSpace—a graphical explorer of the chemogenomic space covered by the ChEMBL database
Bioinformatics·2012· 14 citedOpen Access
Historical Strategies for Lead Generation
2012· 8 cited
The Challenges of Multi-Target Lead Optimization
2012· 15 cited
Identification and optimisation of novel sulfonamide, selective vasopressin V1B receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2011Open Access
Synthesis and SAR studies of novel 2-(6-aminomethylaryl-2-aryl-4-oxo-quinazolin-3(4H)-yl)acetamide Vasopressin V1b receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2011· 7 citedOpen Access
Synthesis and SAR studies of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V1b receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 7 citedOpen Access
Discovery and optimisation of a selective non-steroidal glucocorticoid receptor antagonist
Bioorganic & Medicinal Chemistry Letters·2010· 8 citedOpen Access
Identification and optimization of novel 2-(4-oxo-2-aryl-quinazolin-3(4H)-yl)acetamide vasopressin V3 (V1b) receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2010· 8 citedOpen Access
2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors
Bioorganic & Medicinal Chemistry Letters·2003· 15 citedOpen Access
Reagent concentration effects in the REM resin solid phase synthesis of tertiary amines
Tetrahedron·2003· 6 cited
One-pot Hofmann elimination–transesterification/amidation reactions on REM resin using perfluorous solvents
Tetrahedron Letters·2002· 16 cited
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Frequent Co-authors

Zoran Ranković(14), Paolo F. Ricci(8), Lukas Pfeifer(8), Véronique Gouverneur(8), David Parker(7), Andrew T. Millican(7), John Porter(6), James P. O’Connell(5), Mark York(5), Koc-Kan Ho(5), Gabriele Pupo(4), Francesco Ibba(4), David M. H. Ascough(4), Anna Chiara Vicini(4), John M. Brown(4), Robert S. Paton(4), David C. Rees(4), Wilson Caulfield(4), David R. Barn(4), Michael A. W. Eaton(4)