Brian G. Pierce

University of Maryland, Baltimore — United States

Medicine · Health Sciences

51h-index11.4kcitations168works2.62yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(58), vaccines and immunoinformatics approaches(34), Protein Structure and Dynamics(31), T-cell and B-cell Immunology(26), Hepatitis C virus research(26)

Publications168 total

Antigenicity of key hepatitis C virus E1E2 glycoprotein neutralizing sites is genotype independent
Journal of General Virology·2026Open Access
Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes
Nature Communications·2025· 1 citedOpen Access
Engineering HIV antibodies with enhanced breadth and potency of neutralization through multistate affinity maturation
2025Open Access
Dynamic <i>S</i> -acylation of GSDMA regulates pyroptosis
2025Open Access
Computational Prioritization of T Cell Epitopes to Overcome HLA Restriction and Antigenic Diversity in <i>Plasmodium falciparum</i>
2025· 1 citedOpen Access
Cryo-EM structures of HCV E2 glycoprotein bound to neutralizing and non-neutralizing antibodies determined using bivalent Fabs as fiducial markers
Communications Biology·2025· 2 citedOpen Access
Evaluation of AlphaFold modeling for elucidation of nanobody–peptide epitope interactions
Journal of Biological Chemistry·2025· 3 citedOpen Access
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
Structure·2025· 2 citedOpen Access
Evaluation of Alphafold modeling for elucidation of nanobody-peptide epitope interactions
2025· 1 citedOpen Access
Secretory biogenesis and design of a next-generation coronavirus genetic vaccine
Structural Dynamics·2025Open Access
RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication
Pathogens·2025· 1 citedOpen Access
<scp>AlphaFold</scp> and Docking Approaches for Antibody–Antigen and Other Targets: Insights From <scp>CAPRI</scp> Rounds 47–55
Proteins Structure Function and Bioinformatics·2025· 3 citedOpen Access
Author response for "AlphaFold and Docking Approaches for Antibody-Antigen and Other Targets: Insights From CAPRI Rounds 47-55"
2024
Supplementary Tables S1-S36 from Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy
2024Open Access
Supplementary Figures S1-S25 from Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy
2024Open Access
Structural characterization and AlphaFold modeling of human T cell receptor recognition of NRAS cancer neoantigens
Science Advances·2024· 14 citedOpen Access
Supplementary Tables S1-S36 from Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy
2024Open Access
Supplementary Figures S1-S25 from Preexisting Skin-Resident CD8 and γδ T-cell Circuits Mediate Immune Response in Merkel Cell Carcinoma and Predict Immunotherapy Efficacy
2024Open Access
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV
2024· 1 citedOpen Access
Exploring the potential of structure-based deep learning approaches for T cell receptor design
PLoS Computational Biology·2024· 3 citedOpen Access
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Frequent Co-authors

Zhiping Weng(29), Ragul Gowthaman(11), Howook Hwang(8), Thom Vreven(8), Jeffrey J. Gray(8), Paul A. Bates(8), Juan Fernández‐Recio(8), Johnathan D. Guest(8), Iain H. Moal(7), Alexandre M. J. J. Bonvin(7), Steven K. H. Foung(7), Brian Jiménez‐García(6), Rui Yin(6), Chaok Seok(6), Daisuke Kihara(6), Dima Kozakov(6), Sándor Vajda(6), Zhen–Yong Keck(6), Roy A. Mariuzza(6), Kevin Wiehe(5)