Darren Dressen

Medicine · Health Sciences

10h-index282citations16works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(5), Cell Adhesion Molecules Research(5), Computational Drug Discovery Methods(4), Chemical Synthesis and Analysis(4), Peptidase Inhibition and Analysis(3)

Publications16 total

Modeling stearoyl-coenzyme A desaturase 1 inhibitors to ameliorate α-Syn cytotoxicity in Parkinson's disease
Journal of Emerging Investigators·2024Open Access
Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch
Journal of Medicinal Chemistry·2013· 32 cited
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors
Bioorganic & Medicinal Chemistry Letters·2012· 11 citedOpen Access
Design, synthesis and structure–activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors
Bioorganic & Medicinal Chemistry Letters·2011· 9 citedOpen Access
Discovery of a potent, orally bioavailable pyrimidine VLA-4 antagonist effective in a sheep asthma model
Bioorganic & Medicinal Chemistry Letters·2011· 6 citedOpen Access
Corrigendum to “Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors” [Bioorg. Med. Chem. Lett. 19 (2009) 4920]
Bioorganic & Medicinal Chemistry Letters·2010· 1 cited
Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model
Bioorganic & Medicinal Chemistry Letters·2010· 48 citedOpen Access
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: Structure–activity relationship of the aryl region
Bioorganic & Medicinal Chemistry Letters·2010· 25 citedOpen Access
Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and Efficacious γ-Secretase Inhibitors
Bioorganic & Medicinal Chemistry Letters·2010· 18 citedOpen Access
Design and synthesis of cell potent BACE-1 inhibitors: Structure–activity relationship of P1′ substituents
Bioorganic & Medicinal Chemistry Letters·2009· 31 citedOpen Access
Design, synthesis, and structure–activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline γ-secretase inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 36 citedOpen Access
Preparation and Optimization of a Series of 3-Carboxamido-5-phenacylaminopyrazole Bradykinin B1 Receptor Antagonists
Journal of Medicinal Chemistry·2007· 35 citedOpen Access
Corrigendum to “Synthesis, characterization, and evaluation of pro-drugs of VLA-4 antagonists”[Bioorg. Med. Chem. Lett. 14 (2004) 1651]
Bioorganic & Medicinal Chemistry Letters·2004
Corrigendum to “Synthesis, characterization, and evaluation of pro-drugs of VLA-4 antagonists”
Bioorganic & Medicinal Chemistry Letters·2004· 1 cited
Synthesis, characterization and evaluation of pro-drugs of VLA-4 antagonists
Bioorganic & Medicinal Chemistry Letters·2004· 10 cited
A series of C-Terminal amino alcohol dipeptide Aβ inhibitors
Bioorganic & Medicinal Chemistry Letters·2002· 19 cited

Frequent Co-authors

Andrei W. Konradi(13), Michael P. Bova(9), John‐Michael Sauer(9), Michael A. Pleiss(9), Anh P. Truong(8), Gary D. Probst(8), Hing L. Sham(8), Erich Goldbach(8), Albert W. Garofalo(8), Elizabeth Brigham(7), Kevin P. Quinn(7), Simeon Bowers(6), Roy K. Hom(6), Jing Wu(6), Guriqbal S. Basi(6), David W.G. Wone(5), Karina Wong(5), Ted Yednock(5), Danielle L. Aubele(5), Michael S. Dappen(5)