William H. Tomaszewski

Duke University — United States

Immunology and Microbiology · Life Sciences

10h-index1.2kcitations27works19.52yr avg
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Research Topics

Immune cells in cancer(12), Immune Cell Function and Interaction(8), Neuroinflammation and Neurodegeneration Mechanisms(8), Glioma Diagnosis and Treatment(7), Cancer Immunotherapy and Biomarkers(7)

Publications26 total

Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis
Nature Immunology·2025· 6 citedOpen Access
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion
Immunity·2024· 72 citedOpen Access
IMMU-53. ANTIGEN PRESENTATION BY TUMOR-ASSOCIATED MACROPHAGES MEDIATES PROGENITOR TO TERMINAL EXHAUSTION TRANSITION IN GBM AND OTHER SOLID TUMORS
Neuro-Oncology·2024Open Access
Restriction of innate Tγδ17 cell plasticity by an AP-1 regulatory axis
2024Open Access
Antigen presentation by tumor-associated macrophages drives tumor-infiltrating T cells from a progenitor exhaustion state to terminal exhaustion
2023· 3 citedOpen Access
CD8+ T cells maintain killing of MHC-I-negative tumor cells through the NKG2D–NKG2DL axis
Nature Cancer·2023· 120 citedOpen Access
A Novel MHC-Independent Mechanism of Tumor Cell Killing by CD8 <sup>+</sup> T Cells
2023· 3 citedOpen Access
Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma
Nature Communications·2022· 37 citedOpen Access
BSCI-15 INVESTIGATING CD8 T CELL EXHAUSTION STATES WITHIN THE TME AND DRAINING LYMPH NODE OF PRIMARY BRAIN TUMORS AND BRAIN METASTASES
Neuro-Oncology Advances·2022Open Access
Processed Seurat Object of scRNAseq data from wildtype and CaMKK2 KO immune infiltrate of CT2a preclinical murine glioma
2022Open Access
Processed Seurat Object of scRNAseq data from wildtype and CaMKK2 KO immune infiltrate of CT2a preclinical murine glioma
Zenodo (CERN European Organization for Nuclear Research)·2022· 1 citedOpen Access
Abstract 1378: CD8 T cell mediated killing of MHC class 1 negative tumors requires antigen presenting myeloid cells and interferon gamma
Cancer Research·2022· 1 cited
CD8 T cells licensed with immune checkpoint blockade kill murine tumors lacking MHC-I
The Journal of Immunology·2022
IMMU-34. CAMKK2 PROMOTES AN IMMUNOSUPPRESSIVE PROGRAM AND CHECKPOINT BLOCKADE RESISTANCE IN THE GLIOBLASTOMA TUMOR MICROENVIRONMENT
Neuro-Oncology·2021· 1 citedOpen Access
Broad immunophenotyping of the murine brain tumor microenvironment
Journal of Immunological Methods·2021· 7 citedOpen Access
Targeting Immunometabolism in Glioblastoma
Frontiers in Oncology·2021· 29 citedOpen Access
CaMKK2 deletion increases antitumor potential through enhanced MHC-II expression in Macrophages
The Journal of Immunology·2021
CaMKK2 deletion causes increased accumulation of CD4+ TILs and an improved ratio of effector memory TILs to Tregs
The Journal of Immunology·2021
Abstract 2667: CaMKK2 knockout in mice challenged by orthotopic GBM leads to upregulation of MHC II on TAMs and an increase in accumulation of CD4+ TILs
Cancer Research·2020
Brain Tumor Microenvironment and Host State: Implications for Immunotherapy
Clinical Cancer Research·2019· 314 citedOpen Access
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Frequent Co-authors

Jessica Waibl Polania(14), Peter E. Fecci(11), John H. Sampson(9), Emily Lerner(7), Karolina Woroniecka(7), Daniel Wilkinson(7), Michael D. Gunn(7), Luis Sánchez-Pérez(6), Selena Lorrey(5), Lucas P. Wachsmuth(5), Alexandra Miggelbrink(5), Luigi Racioppi(5), Vincent M. D’Anniballe(4), Xiuyu Cui(4), Mustafa Khasraw(4), Jeffrey R. Capadona(4), Molly A. Chakraborty(4), Jonathan Perera(4), Aditya Mohan(3), Alexandra Hoyt-Miggelbrink(3)