Lucas P. Wachsmuth

Duke University — United States

Engineering · Physical Sciences

11h-index969citations64works3.72yr avg
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Research Topics

Nanoplatforms for cancer theranostics(15), Immune Cell Function and Interaction(13), Cancer, Stress, Anesthesia, and Immune Response(12), Cancer Immunotherapy and Biomarkers(11), Glioma Diagnosis and Treatment(10)

Publications64 total

Central Nervous System Malignancies
2026
Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity
Clinical Cancer Research·2025· 1 citedOpen Access
IMMU-81. Glioblastoma and other intracranial pathologies elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses
Neuro-Oncology·2025Open Access
IMMU-52. Novel Insights into T cell Exhaustion in GBM and other Solid Tumors
Neuro-Oncology·2025Open Access
Supplementary Figure S2 from Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs
2025Open Access
Data from Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs
2025Open Access
Supplementary Figure S1 from Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs
2025Open Access
Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs
Clinical Cancer Research·2025· 2 citedOpen Access
Autonomic modulation of the immune response and implications for CNS malignancies
npj Precision Oncology·2025· 6 citedOpen Access
1055 Intracranial Tumors Elicit Systemic Sympathetic Hyperactivity That Limits Immunotherapeutic Responses
Neurosurgery·2025
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion
Immunity·2024· 72 citedOpen Access
The LITT Fit in neuro-oncology: indications, imaging, and adjunctive therapies
Journal of Neuro-Oncology·2024· 6 cited
IMMU-09. REVERSING SYSTEMIC T CELL DYSFUNCTION TO LICENSE IMMUNOTHERAPY IN INTRACRANIAL TUMORS
Neuro-Oncology·2024Open Access
IMMU-05. TNFR2 IS A NOVEL MARKER OF EXHAUSTION AND TNFR2 BLOCKADE IMPROVES SUBCUTANEOUS TUMOR CONTROL
Neuro-Oncology·2024Open Access
IMMU-53. ANTIGEN PRESENTATION BY TUMOR-ASSOCIATED MACROPHAGES MEDIATES PROGENITOR TO TERMINAL EXHAUSTION TRANSITION IN GBM AND OTHER SOLID TUMORS
Neuro-Oncology·2024Open Access
IMMU-52. A NOVEL MHC-INDEPENDENT MECHANISM FOR CD8+ T CELL KILLING
Neuro-Oncology·2024Open Access
Abstract A056: TNFR2 is a novel marker of exhaustion and TNFR2 blockade improves subcutaneous tumor control
Cancer Immunology Research·2024
IMUN-04 COMBINING CHECKPOINT BLOCKADE AND LASER ABLATION FOR PROGRESSIVE NON-SMALL CELL LUNG CANCER BRAIN METASTASES
Neuro-Oncology Advances·2024Open Access
Upregulation of TNFR2 Precedes TOX Expression by Exhausted T cells and Restricts Antitumor and Antiviral Immunity
2024· 1 cited
Understanding the role of TNFR2 signaling in CD8 T cell exhaustion.
The Journal of Immunology·2024
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Frequent Co-authors

Peter E. Fecci(32), Selena Lorrey(18), Emily Lerner(16), Jessica Waibl Polania(16), Daniel Wilkinson(14), Alexandra Hoyt-Miggelbrink(10), Katayoun Ayasoufi(10), Ethan Srinivasan(10), Aden Haskell-Mendoza(10), Aditya Mohan(7), Christopher G. Kanakry(6), Karolina Woroniecka(6), Alexandra Miggelbrink(6), Xiuyu Cui(6), John B. Finlay(6), Kelly Hotchkiss(6), William H. Tomaszewski(5), Ryan Edwards(5), Christopher L. Mariani(5), Quinn T. Ostrom(5)